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Information × Registration Number 0223U000045, 0120U100084 , R & D reports Title Synthesis, Functionalization and Physicochemical Properties of Biocompatible Ionic Liquids and Surfactants popup.stage_title Head Popov Anatolii F., Доктор хімічних наук Registration Date 01-01-2023 Organization L.M. Litvinenko Institute of Physical-Organic Chemistry and Coal Chemistry of the NAS of Ukraine popup.description2  The objects of research are biodegradable functionalized ionic liquids, antide¬pres¬sants and other drugs, surfactants based on acylpyridinium salts of L-phenylala¬nine, organophosphorus compounds.The purpose of the work is to solve a scien¬tific problem in the field of supramolecular chemistry related to the study of the mechanism of interaction of drugs with other foreign materials, primarily with biological membranes, amphiphilic compounds, which is important when used in the human body. Research methods – NMR, IR-Fourier, UV, and fluorescence spectroscopy, liquid chromatography-mass spectrometry, elemental analysis, po¬tentiometric and conductometric titration methods. Biodegradable ionic liquids based on pyridinium salts and some amino acids, as well as their molecular comp¬lexes with medical preparations, especially with local anesthetic, anti-inflammato¬ry, tranquilizing and antibiotic effects, were obtained. The mechanism of formation of such complexes has been clarified. The use of such biodegradable "green" sol¬vents increases the effectiveness of drugs and allows them to be used as a means of delivery in the human body.The main factors that control the effectiveness of mice¬llar catalysis in reactions of splitting organophosphorus compounds have been es¬ta¬b¬lished based on the analysis of the obtained data on the relationship between the structures of the substrate and surface-active ionic liquids based on pyridinium salts. Product Description popup.authors Burakov Mikola І. Karpichev Eugene A. Kushch Olha V. Мironov Оleg L. Opeida Josyp O. Tamarkina Yuliya V. Tkachuk Yulia V. Shumeiko Olexander E. popup.nrat_date 2023-01-01 Close