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Information × Registration Number 0223U000731, 0122U000576 , R & D reports Title To study the features of the pathogenesis of lung emphysema in the patients with bronchial asthma who have had a COVID-19 and to work out the technology for their treatment (clinical and experimental studies) popup.stage_title Head Feschenko Yurii I., Доктор медичних наукYashyna Liudmyla O., д.мед.н. Registration Date 19-01-2023 Organization State organization "National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky National academy of medical sciences of Ukraine" popup.description2  Object – 90 patients with bronchial asthma (60 – those who have had a COVID-19); 24 white laboratory rats. Aim – to increase the effectiveness of the treatment of bronchial asthma patients who have had a COVID-19, taking into account the features of the pathogenesis of lung injury and clinical, functional characteristics. Methods – questionnaire, clinical, functional, radiological, laboratory, experimental, statistical. The clinical characteristics of the asthma patients who have had a COVID-19 are uncontrolled asthma ((12,2  0,4) ACT points), a high dyspnea level ((2,0  0,1) mMRC points), the presence of depression and a severe fatigue. The functional characteristics are: a decreased vital and forced vital capacity, which indicate restrictive lung disorders; a decreased FEV1 (65,7  2,1) % and MEF25 (32,8  2,4) %, which indicate the higher level of small bronchi obstruction; a decreased the respiratory muscles strength; decreased tolerance to physical activity. In experimental pulmonary emphysema the increased generation of MDA leads to the development of oxidative stress, violation of the functions of the antioxidant and antiperoxide systems, as evidenced by a decreased ceruloplasmin level and catalase activity in the blood. The mechanisms of biochemical disorders in asthma patients who have had COVID-19 and pulmonary emphysema are a decrease of the total protein content and signs of liver dysfunction. In asthma patients who have had a COVID-19 predominates the neutrophilic type of airway inflammation. An diagnostic algorithm of respiratory muscle dysfunction in patients with bronchial asthma after COVID-19 at the primary medical care level has been developed, which has high sensitivity (89,8 %) and specificity (81,8 %) and makes it possible to increase the accuracy of the diagnosis of respiratory muscle dysfunction by 18,3 % compared to the determination of only PImax and PEmax (from 70,0 % to 88,3 %). Sphere of application – therapy, pulmonology, allergology Product Description popup.authors Ignatieva Victoria I Vlasova Nataliya A Halai Liudmyla A Gymeniuk Galyna Lvivna Zvol Inna V Korzhov Vitaly I Kuryk Lesia M Moskalenko Svitlana M Opimakh Svitlana G Parkhomenko Nataliya V Polianska Maryna O Prymushko Nataliya A Feshchenko Yuri I Chumak Irina V Yashyna Lyudmyla O popup.nrat_date 2023-01-19 Close