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Information × Registration Number 0223U000937, 0119U102387 , R & D reports Title Determination of the role of deficiency and deficiency of vitamin D in the development of sexual dysfunctions, justification of approaches to their therapy popup.stage_title Head Bondarenko Volodymyr O., Доктор медичних наук Registration Date 22-01-2023 Organization State Institution “V.Ya.Danilevsky Institute of Endocrine Pathology Problems of Academy of Medical Sciences of Ukraine” popup.description2  It has been established that in women with PCOS, vitamin D deficiency (vit. D) increases hyperandrogenism, increases existing disorders of carbohydrate and lipid metabolism, indicators of chronic inflammation, homocysteine ​​and nitrate-nitrite levels. The addition of cholecalciferol to metformin therapy in the treatment of PCOS leads to a more significant reduction in insulin resistance and an improvement in the lipid profile. It has been shown that spermatogenesis disorders in men can be associated with hypofunction of the thyroid gland against the background of vitamin deficiency. D in the autumn-winter period. It has been proven that during the treatment of infertility in men, the normalization of all parameters of spermograms occurs significantly more often when optimal levels of vit are reached. D in the blood. It is shown that the predictor of the formation of erectile dysfunction in patients with type 2 diabetes is a decrease in testosterone in the blood against the background of D-hypovitaminosis. Normalization of the level of vit. D in the blood when using cholecalciferol is essential for improving erectile function in these patients. A study of the action of adding vit. D3 to schemes for correction of incretory, generative and copulatory function disorders in rats with hypofertility of various genesis (prostatopathy and gonadopathy). Its antioxidant properties and the possibility of increasing the effect of testosterone on the seminal vesicles have been revealed. It is shown that the use of vit. D, together with Tribestan or Prostatylen, has a positive effect on the spermogram indicators that have arisen as a result of experimental reproductopathies. Application of vit. D3, together with drugs for the basic therapy of hypofertility, is effective,leading to the prevention of damage to the histostructure of the testicle in gonadopathy and the prostate gland in prostatitis, which is a prerequisite for the restoration of spermatogenesis in full in the future Product Description popup.authors Arkhypkina Tetiana L. Belkina Inna O. Boyko Marina O. Brechka Nataliia M. Goncharova Olga A. Koreneva Eugenia M. Kustova Svetlana P. Lyubimova Lydia P. Minukhin Andrey S. Perets Olena V. Selyukova Natalya Yu. Sidorova Iryna V. Skornyakov Yevgen I. Smolenko Natalia P. Tjazhelova Ol'ga V. Khyznyak Oksana О. Chistyakova Elina E. popup.nrat_date 2023-01-22 Close