Registration Number
0223U001477,
0118U003377
, R & D reports
Title
Physical effects and mechanisms of interactions of biological molecules and supramolecular biological systems with nanoparticles and nanostructured media.
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Head
Dovbeshko Halyna I.,
Registration Date
28-01-2023
Organization
Institute of Physics of National Academy of Sciences of Ukraine
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The physical effects and mechanisms of interaction of bioorganic molecules (nucleotide bases - adenine, thymine, lipids - dioleoylphosphatidylcholine, phosphatidylserine, sphingomyelin, cholesterol, etc.), biological macromolecules - proteins of lysozyme, albumin, oligonucleotides, nucleic acids and supramolecular nanoscale biological systems (biological membranes, lipid aggregates) were studied , protein complexes, living cells) with nanoparticles - MoS2, WS2, BN, graphene oxide and nanostructured media of different nature (carbonic, metallic, organic, mineral, combined) in order to identify patterns of such interactions. The methods of experimental spectroscopic research and microscopic research (contrast increase by 10 times, staining without dyes) have been improved thanks to new equipment and mathematical processing, and a number of spectroscopic markers have been developed for membranes of different composition, mitochondria, synaptosomes, brain tissues. New computational algorithms and data analysis methods for their in silico study are proposed.
Product Description
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Yesylevskyy Semen Oleksandrovych
Andreev O Yevgen leksandrovych
Barabash Yurii M.
Boyko Vitaliy Volodymyrovuch
Hanulia Taras Oleksandrovych
Gnayuk Olena P
Dovbeshko Galyna Ivanivna
Lebedieva Tetiana Oliksiivna
Olenchuk Maryna Volodymyrivna
Polovyi Ivan Oleksandrovych
Fedorov Volodymyr Olegovych
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2023-01-28
