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Information × Registration Number 0223U001623, (0120U100120) , R & D reports Title Improve the range of therapeutic and diagnostic measures and identify epigenetic risk factors for oncogenicity in women with infertility and hyperproliferative syndrome popup.stage_title Удосконалити комплекс лікувально-діагностичних заходів та визначити епігенетичні фактори ризику онкогенності у жінок з безплідністю і гіперпроліферативним синдромом Head Kornatska Alla H., Доктор медичних наукTrokhymovich Olha V., Доктор медичних наук Registration Date 01-02-2023 Organization State institution "Institute of Pediatrics Obstetrics and Gynecology named academic Elena M. Lukyanova National Academy of Medical Sciences of Ukraine" popup.description1 Restoration of reproductive function of women with infertility and hyperproliferative syndrome based on the study of clinical features, hormonal homeostasis, morpho-functional status of target organs, immunohistochemical markers of pathological process development and epigenetic risk factors popup.description2  The factors contributing to the development of infertility in women with hyperproliferative pathology of the uterus have been established. The most common triggers were inflammatory processes of the genitals (51%), abortions (28%), thyroid pathology (26.3%), and genetic factors (44%). Based on the pathomorphological and immunohistochemical study of the endometrium of women with hyperproliferative pathology of the uterus, the pathogenetic mechanisms of the development of infertility were clarified, which consisted in changes in the receptivity of the endometrium, dysregulation of the processes of apoptosis and proliferation at the local level, which may be the cause of the disruption of the mechanism of blastocyst implantation. The histological and immunohistochemical features of endometrial pathomorphosis after hormone therapy with drugs of different mechanisms of action, which should be taken into account in women with infertility, have been established. Determination of epigenetic mechanisms of reproductive function disorders in women with hyperproliferative pathology of the uterus based on the study of miRNA status. The association of miRNA expression levels with the presence of infertility, the development of uterine leiomyoma, its size and the number of myomas nodes and the presence of concomitant pathology was established. Based on the obtained data, predictive miRNA panels were developed to determine sensitivity to hormonal drugs with different mechanisms of action. An algorithm for determining sensitivity to hormone therapy is scientifically substantiated and proposed, which allows for a differentiated approach to treatment. Based on the results of the work, a diagnostic algorithm and a differentiated personalized approach to the treatment of women with hyperproliferative syndrome and infertility were developed and implemented, which allows to increase its effectiveness and reduce the frequency of early pregnancy losses. Product Description popup.authors Baranetcka Irina O. Borysiuk Oleh Yu. Hgasparyan Karine A. Hryshyna Tamara О. Danylenko Olena H. Dybchak Alla E. Zadorozhna Tamara D. Kondratiuk Valentyna K. Корнацька Алл Григорівна Lisyana Tamara O. Lukianova Nataliia Yu. Poluianova Oksana M. Ponomarova Inna H. Revenko Oleh O. Trokhymovych Olha V. Chubei Halyna V. popup.nrat_date 2023-02-01 Close