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Information × Registration Number 0223U001796, 0122U001207 , R & D reports Title To define the regularities of forming and influence of cellular aging on the course of coronary heart disease in association with comorbid pathology during long-term follow-up of persons involved in emergency work at the Chernobyl nuclear power plant popup.stage_title Head Bilyi Davyd О., Доктор медичних наукBazyka Dymytrii A., Доктор медичних наук Registration Date 03-02-2023 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2 It was established that coronary heart disease (CHD) in emergency workers (EW) develops at a younger age (by 4.4 years) and earlier (by 4 years after the accident) compared to controls. There was a deterioration of of coronary artery disease course, an increase in the number of patients with angina pectoris of more severe Ⅲ and Ⅳ functional class, heart failure of a higher stage. At the end of the 35th year of the post-accident period, there was a significant increase in left ventricle (LV) volumes in EW and control group, the proportion of EW with LV systolic dysfunction increased significantly, with only a trend in control. A decrease in EW with concentric LV hypertrophy by 31.8% (p < 0.01) and an increase with eccentric LV hypertrophy by 30% (p < 0.05) were determined. The occurrence of prognostically dangerous types of arrhythmias was registered in EW by 11.8% more often than in controls (p < 0.05). There was a decrease in most indicators of heart rate variability, an increase in sympathetic control. No correlation was found between the relative length of telomeres and age, radiation dose and indicators of cellular immunity. Product Description popup.authors Ilienko Iryna Mykolaivna Belyi David O. Bazyka Dymytrii А. Bazyka Olexander D. Zvarych Liliaa M Koval'ov Oleksandr S. Kursina Natalia V. Lyaskivska Olena V. Nastina Оlena M. Sydorenko Gennagyi V. popup.nrat_date 2023-02-03 Close