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Information × Registration Number 0223U001819, 0119U101809 , R & D reports Title Develop rehabilitation programs for mobilizing processes of compensatory-adaptive neuroplasticity in Parkinson's disease popup.stage_title Head Voloshyna Nataliia P., Доктор медичних наук Registration Date 03-02-2023 Organization State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine" popup.description2  The object of the study: patients with Parkinson's disease (PD). Purpose of research work (RW): Justification, development and evaluation of the effectiveness of non-drug rehabilitation programs, which focus on the mobilization of adaptive and compensatory neuroplasticity and determination of their influence on the quality of life and clinical-pathogenetic mechanisms in PD. Research methods: questionnaire, clinical-neurological, neuropsychological, biochemical, statistical. The practical significance of the phenomenon is shown based on the research on paradoxical kinesia (PK in the implementation of motor rehabilitation programs in the case of Parkinson's, as well as in overcoming loads of the period of force majeure events. An assessment of the clinical manifestations of the phenomenon of PK and factors contributing to it. This describes the cohort of patients most focused on using rehabilitation programs using the paradoxical phenomenon of kinesia. It is shown that the realization of the phenomenon of PK with the help of factors that contribute to it can be used when conducting regular motor rehabilitation classes, but preserved cognitive potential is necessary for patients. It was found that rehabilitation programs provide positive dynamics in the system of neurotrophic factors. There is a synchronous dynamics of indicators CDNF and GDNF, which correlates with positive neuroplasticity, which clinically was manifested as a modification of the course of PD by more favourable. It has been proven that in conditions of force majeure, the full execution of the program motor rehabilitation using the phenomenon of PK online and off-line modes with continued implementation of recommendations from regular motor rehabilitation is a means of improving the state of the psycho-emotional sphere, reducing expressiveness of psychopathological symptoms, primarily depressive and anxiety, as well as improving the quality of life in patients with PD. Product Description popup.authors Bohdanova Taisiia Volodymyrivna Bohdanova Iryna Vyacheslavivna Vasylovskyi Vitalii Voloshyn-Haponov Ivan Kostiantynovych Mishina Larysa I. Petrukhina Nina Dmytrivna Pogulyayeva Tetyana Mykolaiivna Prilepa Valentina Olexandrivna Sokolik Viktoriya V. Tereshchenko Ludmyla P. Fedoseyev Serhiy Volodymyrovych popup.nrat_date 2023-02-03 Close