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Information × Registration Number 0223U002460, 0119U103964 , R & D reports Title The role of alarmin amphotherine, syrtuins and nanoparticles of metals under conditions of immune-induced disorders of the female reproductive system popup.stage_title Head Yanchii Roman I, Доктор біологічних наук Registration Date 21-02-2023 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  New data were obtained that, under conditions of oxidative-nitrosative stress, SIRT 1 participates in the regulation of repair of DNA single-strand breaks in cells of the follicular environment of oocytes. This provides some progress in justifying new approaches aimed at reducing DNA damage, and thus in identifying possible therapeutic targets for correction of reproductive disorders in women. Suppression of amphoterin (НМGB1) with the help of ammonium glycyrrhizinate inhibitor was established in mice with experimental endotoxemia. It was shown that the use of ammonium glycyrrhizinate prevents the development of oxidative stress and improves antioxidant protection, which indicates the promise of further research on the use of HMGB1 inhibitors for the treatment of diseases induced by the endotoxin of gram-negative bacteria. Key words: single-strand DNA breaks, oocyte follicular cells, sirtuins, repair, oxidative-nitrosative stress, ammonium glycyrrhizin, liver homogenate, experimental endotoxemia. Product Description popup.authors Blashkiv Taras V. Voznesenska Tetiana U. Grushka Nataliya G. Kaleynikova Oksana M. Kondratska Olena А. Krasutska Natalya O. Litvinenko Аlina P. Pilkevych Natalia O. Pavlovych Svitlana I. Svarichevsky Oleg V. Sribna Valentyna O. Yanchiy Roman I. popup.nrat_date 2023-02-21 Close