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Information × Registration Number 0223U003321, 0120U101488 , R & D reports Title Development of therapeutic interventions for severe variants of pervasive disorders based on the association of genetic polymorphism with clinical manifestations popup.stage_title Head Martsenkovsky Igor A., Кандидат медичних наук Registration Date 16-04-2023 Organization State Institution "Institute of Psychiatry, Forensic Psychiatric Examination and Drug Monitoring of the Ministry of Health of Ukraine" popup.description2  Report: 30 pp., 9 tables, 9 figure, 17 sources. The object of the study is children with autism spectrum disorders with genetic and clinical polymorphism in the form of comorbidity with psychotic and epileptic disorders. The aim is to study the relationship of individual genotypes with the polymorphism of clinical manifestations based on a systemic approach, to develop and implement therapeutic interventions for polymorbid pervasive disorders. Research methods — genome association scanning (GWAS), clinical and anamnestic, socio-demographic, pathopsychological, clinical and psychopathological, psychodiagnostic, statistical. Objectives of the study: 1. To conduct a comparative study of the clinical course of autism spectrum disorders in individuals with genetic polymorphism variants and individuals with psychotic symptoms and epileptic seizures in the anamnesis without corresponding genetic polymorphism variants. 2. To investigate the significance of the influence of environmental factors, psychotropic and neurotropic drugs on the expression of psychotic disorders, epileptic seizures in certain variants of genetic polymorphism. 3. To investigate the effectiveness of therapeutic interventions in severe variants of the course of autistic spectrum disorders, complicated by psychotic symptoms and epileptic seizures. 4. On the basis of a systemic approach, scientifically substantiate, develop and implement a complex of therapeutic interventions for children with polymorbid pervasive disorders in practical health care institutions. AUTISM SPECTRUM DISORDERS, EPILEPTIC SEIZURES, PSYCHOTIC DISORDERS, THERAPEUTIC INTERVENTIONS. Product Description popup.authors Vashchenko Olesya S. Zdoryk Iryna F. Makarenko Hanna V. Martsenkovska Inna I. Skrypnyk Tetiana O. Chepurna Alina M. popup.nrat_date 2023-04-16 Close