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Information × Registration Number 0223U003842, 0119U002288 , R & D reports Title Genetic predispositions of regular and sporadic reproductive losses in humans. popup.stage_title Head Zastavna Danuta V., Registration Date 11-07-2023 Organization State institution "Institute of Hereditary Pathology of the National Academy of Medical Sciences of Ukraine" popup.description2 The obtained results allow us to argue the extreme relevance of the multilevel study of genome structures involved in the mechanisms of self-reproduction of the human population. We propose to informative markers of predisposition to regular reproductive losses include the presence of chromosomal pathology in eliminated fetuses with karyotypes that are not found among live births and critically short telomeric regions of chromosomes. We consider HLA-genotyping of spouses with isolation of risk factors of alloimmune and autoimmune nature and KIR-HLA-C-genotyping of a woman and her lost pregnancy to be extremely informative for preconception prevention of repeated reproductive losses. For the purpose of preconception prevention of reproductive losses, genetic testing of persons at risk is appropriate. Our detection of 301 hereditary diseases by the new generation sequencing method (NGS) showed the carrier of mutated genes in 87.5% of subjects with reproductive history. To improve the system of prevention and early diagnosis of monogenic pathology, effective medical and genetic counseling, it is proposed to include genetic testing of families with reproductive losses to predict healthy offspring when planning a pregnancy. Product Description popup.authors Helner Nadiia V. Huleyuk Nataliya L. Zastavna Danuta Lozynska Marya R. Makukh Halyna Vasulivna Sosnina Katerina Oleksandrivna Terpylyak Oresta Igorivna Tyrkus Marta Tkach Iryna R. Tretiak Bogdan Chorna Liliia Sharhorodska Yevgeniya popup.nrat_date 2023-07-11 Close