Search academic texts

Information × Registration Number 0223U004417, 0117U005021 , R & D reports Title The study of the mechanisms of pleiotropic effects of recombinant interferon alpha on the body popup.stage_title Head Beschasnyi Serhii P., Кандидат біологічних наук Registration Date 29-10-2023 Organization Kherson State University popup.description2 Research Object - the activity of the actin-myosin complex in muscles under the influence of interferons with varying biological activity. Purpose of the Study - to investigate the effect of recombinant interferons with different biological activities on the actin-myosin complex of muscles. Research Methods - colorimetric and biochemical methods were employed to assess the influence of interferons on the function of the actin-myosin complex. The data obtained were analyzed using non-parametric statistical methods, with the use of the Mann-Whitney criterion. The study examined the non-immunological impact of recombinant interferon preparations. Specifically, it was the first time that the ATPase activity of the actin-myosin complex and the content of creatine phosphate in muscles under the influence of the immunobiological preparation were determined. It was also demonstrated for the first time that high concentrations of recombinant interferons lead to a reduction in the quantity of macro-energetic compounds in muscles. A regularity was established that explains the side effects of interferon preparations, especially when used in high therapeutic doses. Thus, it was first determined that the administration of interferons with high biological activity induces myalgia by reducing the activity of macro-energetic compounds in muscles, which suppresses the contractile ability of the actin-myosin complex. Keywords: actin-myosin complex, interferon alpha, ischemia-reperfusion, muscles, myocardium, ATPase activity, creatine phosphate, isolated heart, coronary perfusion.   Product Description popup.authors Beschasnyi Serhii P. popup.nrat_date 2023-10-29 Close