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Information × Registration Number 0223U004543, 0118U001903 , R & D reports Title Search and study of biologically active substances among natural compounds and products of chemical synthesis popup.stage_title Head Voloshchuk Nataliia I., Доктор медичних наук Registration Date 16-11-2023 Organization Vinnytsia National Pirogov Memorial Medical University popup.description2  Pharmacodynamics, pharmacokinetics and mechanisms of action of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide derivatives and their crystal modifications, nephro- and cardioprotective properties of plant polyphenols, sex-specific frigoprotective effect of glucosamine were the subject of the research hydrochloride, cerebroprotective properties of ademol for craniocerebral trauma. The object of the research is the pharmacological correction of acute and chronic inflammatory processes, the relationship between structural polymorphism, pharmacodynamics and pharmacokinetics of 2,1-benzothiazine-3-carboxylic acid derivatives and GABA-modified monoase-15-crown-5, nephro-, participation hydrogen sulfide systems in the organoprotective effect of plant plant polyphenols in experimental lesions of the heart and kidneys, gender differences in the treatment of acute cold injury with glucosamine, as well as pharmacotherapy of craniocerebral injury with the NMDA receptor modulator (ademol). The aim of the work was to search for promising substances with analgesic and anti-inflammatory effects among new chemical compounds, derivatives of N-aryl(hetaryl)-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3- carboxamide and their crystal modifications, as well as to experimentally substantiate the improvement of pharmacotherapy of chronic kidney disease, alcoholic cardiomyopathy and acute cold injury with drugs containing plant polyphenolic compounds (quercetin, genistein, resveratrol) and glucosamine by modulating hydrogen sulfide metabolism and taking into account gender and level sex hormones. It was also necessary to experimentally substantiate the increase in the effectiveness of primary cerebroprotection in case of craniocerebral trauma, by using the modulator of the polyamine site of NMDA-receptors ademol for a new purpose, with the further development of a new dosage form based on it. Product Description popup.authors popup.nrat_date 2023-11-16 Close