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Information × Registration Number 0223U005008, 0123U102876 , R & D reports Title The role of mitochondrial mechanisms in the development and prevention of cardiovascular dysfunctions in aging popup.stage_title Head Sahach Vadym F., д.мед.н. Registration Date 13-12-2023 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  A new method of increasing mRNA expression of the genes of the H2S-synthesizing enzymes CSE and 3-MST was developed, which consists of the sequential intraperitoneal administration of DL-propargylglycine (PAG) (11.3 mg/kg) and L-cysteine (121 mg/kg). Their administration restored the expression levels of CSE and 3-MST in the heart of old rats to the level of adult rats and significantly increased the levels of hydrogen sulfide in the heart tissue and mitochondria of old rats. For the first time, it was shown that administration of PAG and L-cysteine to old rats significantly improved the recovery of the function of the ischemic heart during reperfusion, and was accompanied by a reduction in oxidative stress and restoration of constitutive nitric oxide synthesis. For the first time, administration of PAG and L-cysteine to old rats has been shown to significantly improve mitochondrial function. Product Description popup.authors Denisova Mayya V. Korkach Yulia P. Mishchuk-Vozna Olga V. Mys Lidiya A. Okhay Iryna Y. Sahach Vadym F. Strutynska Natalia A. Strutynskyi Ruslan B. popup.nrat_date 2023-12-13 Close