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Information × Registration Number 0223U005785, 0121U111450 , R & D reports Title To develop a method for determining the magneto-optical properties of biogenic and synthetic functionalized iron-containing nanoparticles, suitable for the study of blood coagulation factors and fibrinolysis popup.stage_title Head Danysh Taras Vasylovych, Кандидат біологічних наукNovak Vasyl L., д.мед.н. Registration Date 31-12-2023 Organization State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine" popup.description2 129 pp., 11 tables, 17 figures, 5 supplements, 116 citations. MAGNETIC NANOPARTICLES, MAGNETO-OPTICAL ANALYSIS, BIO-SPECIFIC FUNCTIONALIZATION, FACTORS OF BLOOD COAGULATION AND FIBRINOLYSIS. The object of the study is the method of determining the dependent dynamic parameters of synthesized iron-containing nanoparticles; processes of obtaining magnetic nanoparticles. The purpose of the work is to increase the accuracy of laboratory studies of blood coagulation factors and fibrinolysis using the developed magneto-optical method and the efficiency of the technology of obtaining them from blood plasma by using synthesized iron-containing nanoparticles. Research methods: magneto-optical analysis; chemical synthesis; magnetic separation; photometric; coagulological; statistical. The following results were obtained: synthesis of iron-containing nanoparticles with sizes of 50-500 nm; developed conditions for their covalent conjugation with biospecific ligands using water soluble carbodiimides; their physical and chemical properties were investigated; their influence on the activity of blood clotting factors and fibrinolysis was determined; it has been confirmed that MNPs can be suitable for the analysis of blood clotting factors and fibrinolysis, for the modernization of technological schemes for the isolation of protein factors of blood plasma by the method of magnetic affinity chromatography and the rapid removal of virus-inactivating substances in the process of creating new bioanalytical methods for clinical diagnostics and therapeutic hemostatic materials. Degree of implementation: acts of implementation, reports at international scientific forums, publications in scientific literature. Field of application: blood centers, research organizations. Efficiency. Improvement of technologies for obtaining diagnostic and therapeutic protein preparations. 8 scientific works were published, including 1 article, 7 abstracts of reports at international forums abroad. Product Description popup.authors Danysh Olha Yo. Dovgan` Anatoly Petrovych Dulceva Natalia Anatolyivna Madych Sofiya Yevgenivna Orlova Liubov Volodymyrivna Shurko Natalia Olehivna popup.nrat_date 2023-12-31 Close