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Information × Registration Number 0223U005807, 0122U000439 , R & D reports Title Synthesis and evaluation of antitumor activity of new heterocyclic and organophosphorus compounds popup.stage_title Head Vovk Andrii І., Registration Date 31-12-2023 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description2 Preparative methods for the synthesis of new phosphorylated azoles were developed and their in vitro biotesting was carried out on various model lines of malignant cells. The interaction of 5-formylpyrimidines with aminopyrazoles was studied. Chiral synthetic blocks based on aminophosphonate derivatives were synthesized, methods of obtaining new phosphorus analogues of natural compounds were developed. Prediction of bioactivity was carried out and new synthetic inhibitors of therapeutically important enzymes were studied. Product Description popup.authors Ivanova Irina V. Biletskii Igor І. Bagreeva Oksana S. Brovarets Volodymyr S. Mykhailo Y. Brusnakov Buldenko Vladyslav M. Velihina Yeheniia S. Verves Evgeniy V. Roman M. Vydzhak Herasymov Yehor S. Oleksandr V. Golovchenko Grishkun Evgeny V. Demydchuk Bogdan A. Zhirnov Viktor V. Zyabrev Volodymyr S. Kachaieva Maryna V. Oleksiy D. Kachkovsky Kobzar Oleksandr L. Kozachenko Olexandr P. Anastasiya O. Kolodiazhna Kolodiazhna Olga O. Kolodiazhnyi Oleh I. Kondratyuk Kostyantyn M. Artem S. Konovalenko Kucher Oleksandr V. Losʹ Oleksandr V. Lyutenko Nataliya V. Mityukhin Оleg P. Danylo O. Merzhievskiy Mykula Mariya S. Moskvina Viktoria S. Mrug Galyna P. Muzychka Liubov V. Muzychka Oxana V. Pilyo Stepan Hr. Panchyshyn Svitlana Ya. Porhun Svitlana V. Potikha Lyudmyla M. Prisyajnyuk Dmitry V. Prokopenko Volodumir M. Prostota Yaroslav O Severin Oleksandr O. Synenko Vitaliy O. Slyvchuk Serhiy R. Smolii Oleh B. Solomyanyi Roman M. Sukhoveev Olexandr V. Танчук Всеволод Юлієвич Tatarchuk Alʹona V. Frasinyuk Mykhaylo S. Chumachenko Svitlana A. Shablykin Оleg V. Olha V. Shablykina Shejko Sergij Yu. Yrij V. Shulga Yaremchuk Iryna О. popup.nrat_date 2023-12-31 Close