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Information × Registration Number 0224U000159, 0121U111613 , R & D reports Title To research cytogenetic, immunological and functional properties of blast cells in acute leukemias with maturation and to determine their clinical significance popup.stage_title Head Lohinskyi Volodymyr Ye., Доктор медичних наукShalai Olha O., Кандидат медичних наук Registration Date 03-01-2024 Organization State institution "Institute of blood pathology and transfusion medicine of Nataional Academy of Medical scinces of Ukraine" popup.description2 The object of the study was 70 patients with acute leukemia (AL). The aim of the work was to determine the relationship between cytogenetic and molecular genetic aberrations of blast cells with immunophenotypic markers, immunological, biochemical and clinical course features of acute leukemias with maturation. Clinical, cytological, cytochemical, immunophenotypic, cytogenetic, FISH, biological, statistical research methods were used. The analysis of clinical and hematological features, morphological, immunophenotypic, cytogenetic and functional features of blast cells was conducted, the concentration of cytokines was investigated and the nature and degree of correlation of their level depending on the severity of anemia and thrombocytopenia were determined in AL with maturation, risk groups were determined and survival was analyzed. The variant of AL was confirmed according to the WHO classification (2022). Cytogenetic rearrangements of various kinds associated with AML M3 and AML M5 were found in 73 % of patients. The PML/RARа gene, t(15;17)(q22;q21), tetrasomy 8 were detected in AML M3. The 11q23/MLL (KMT2A) rearrangement - del(11)(q23), BCR/ABL gene, t(9;22)(q34;q11), +8 were found in AML M5. The statistical analysis of the patient survival according to the selected prognosis groups with cytogenetic markers was carried out, which allows choosing the most optimal treatment tactics. The results of the work were implemented in the SI "Institute of Blood Pathology and Transfusion Medicine of the National Academy of Medical Sciences of Ukraine" and MNE "Lviv Territorial Medical Union "Clinical Hospital for Planned Treatment, Rehabilitation and Palliative Care". Scope is oncohematology. Product Description popup.authors Barilka Vira Anatoliyivna Zotova Olena Vasylivna Karol Yuriy Stepanovych Krasivska Valeriya Valeriivna Matlan Volodymyr Lvovych Myhal Ivan Ivanovich Rymar Maria Mykhaylivna Shalai Olha Oleksiyivna Yasnysky Zenoviy Ilkovych popup.nrat_date 2024-01-03 Close