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Information × Registration Number 0224U000468, 0121U107438 , R & D reports Title Investigation of the influence of 137Cs and C262T incorporated polymorphism of the CAT gene encoding catalase on the development of disorders in the respiratory system and substantiation of criteria for predicting bronchopulmonary pathology in children in the remote period of the Chernobyl disaster popup.stage_title Head Kolpakov Igor Ye., Доктор медичних наук Registration Date 08-01-2024 Organization State Institution "National Research Centre For Radiation Medicine of National Academy of Medical Sciences of Ukraine" popup.description2  Accumulation of 137Cs in the body in the range from 126 to 9994 Bq increases the intensity of free radical oxidation processes, which is evidenced by an increase in the content of lipid peroxidation products in the blood and changes in the activity of superoxide dismutase, ceruloplasmin and catalase antioxidants. The presence of genotypes and alleles of the C-262T polymorphism of the catalase gene is associated with an increase in superoxide dismutase activity in ST and TT genotypes and the T allele, and a decrease in its activity in the SS genotype and C allele, as well as a decrease in catalase activity in the TT genotype. It was shown that the presence of the T allele in polymorphic variants C262T of the CAT gene is associated with bronchial hyperreactivity. Polymorphisms of the SAT gene with a mutant T allele in combination with the effect of the radiation factor, certain constitutional features of the child and a heavy family history are predictors in the realization of brochopulmonary pathology and prognostically unfavorable criteria for its course. Product Description popup.authors Vdovenko Vitaliy Yu. Zygalo Viktor M. popup.nrat_date 2024-01-08 Close