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Information × Registration Number 0224U001013, (0123U101246) , R & D reports Title Development of new highly economical methods of biomarker diagnostics and prediction of the course and complications of COVID-19 and community-acquired pneumonia in military personnel and civilians popup.stage_title Розробка нових високоекономічних методів біомаркерної діагностики і прогнозування перебігу та ускладнень COVID-19 і позагоспітальної пневмонії у військовослужбовців і цивільного населення. Head Komarevtseva Iryna O., д.мед.н. Registration Date 16-01-2024 Organization The State Institution "Lugansk State Medical University" popup.description1 To develop new highly economical methods of biomarker diagnostics of apoptosis, inflammation, dysfunction of the glycocalyx and antiprotease system in predicting the course and complications of COVID-19 and community-acquired pneumonia in military personnel and civilians, including pregnant women. popup.description2  A retrospective collection of clinical material (55 sick servicemen) was carried out on the basis of the Rivne Regional Hospital of War Veterans and ATO, according to the data of clinical and instrumental research methods, the structure and nature of lung diseases, as complications of combat trauma, non-traumatic emergency lung conditions, in particular, pneumonia and complications of COVID- 19 for military personnel. The use of standardized scales for assessing the severity of pneumonia, IDSA/ATS criteria, the CRB-65 scale, as well as the scale with the addition of a laboratory assessment of urea level (CRUB-65), as well as the PORT/PSI and SMART-COP scales, were analyzed. Taking into account the resource capabilities of Ukrainian hospitals, we developed, tested and used in our research a modified scale, which we called DUSS according to the indicators: respiratory insufficiency I - II stage.; complications of the main disease; accompanying diseases; saturation: SaО2 < 94%; СаО2 < 90%. Analysis of circulating cell-free DNA (cfDNA), mediator of the antiprotease system (alpha-1-antitrypsin), sphingosine-1-phosphate in patients with COVID-19 (including pregnant women), community-acquired pneumonia was performed with the aim of determining these indicators as biomarkers of severity and course of diseases. According to ROC analysis (MedCalc Version 20.218, MedCalc Software, Ostend, Belgium) our results showed that cfDNA, alpha-1-antitrypsin, sphingosine-1-phosphate profiles can distinguish patients with COVID-19 and community-acquired pneumonia at risk of severe disease and death with greater efficiency than markers previously reported inflammation. We found that non-pregnant women with COVID-19 had lower alpha-1-antitrypsin levels than healthy non-pregnant women. Alpha-1 antitrypsin levels were approximately 1.5 times lower in the group of preterm pregnant women with COVID-19 than in pregnant women with COVID-19 who delivered at term. Product Description popup.authors Ihnatova Anna Yu. Balabanova Kateryna V. Burachyk Andrii I. Hliebova Tetiana M. Zhurba Oleksandr A. Posternak Dmytro H. Rudenko Iryna V. Cherednychenko Roman V. Chernykh Yurii A. popup.nrat_date 2024-01-16 Close