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Information × Registration Number 0224U001109, 0122U001269 , R & D reports Title Development of novel means of medical diagnostics by biomedical nanotechnologies and modern ultrasonic and fluorescence methods popup.stage_title Head Horbenko Halyna P., д.ф.-м.н. Registration Date 17-01-2024 Organization V.N. Karazin Kharkiv National University popup.description2  A theoretical model of exciton luminescence of Y2O3 ceramics sintered from nanopowder is presented. It is shown that the effect of additional heat treatment on the luminescence spectrum in the STE region can be explained by the changes in the coupling of excitons with phonons. An increase in the frequency of phonons, which leads to a decrease in the energy of photons of STE luminescent radiation, is calculated. A quantitative physico-mathematical model of luminescence of polycrystalline yttrium oxide samples under long-term irradiation was developed due to the presence of defects in polycrystalline samples and their capture of some high-energy photoelectrons before slowing down immediately, as natural traps. The probability of nonradiative relaxation after capture is directly proportional to the concentration of captured high-energy electrons. As a result, with an increase in the concentration of captured photoelectrons, the share of high-energy photoelectrons, which subsequently participate in the formation of STE per unit of time, will decrease. The possibility of functionalizing insulin nanofibrils using a cascade of fluorophores was evaluated. The styryl pyridinium dyes (SPDs) containing alkyl chains, display a more pronounced ability to serve as relay fluorophores than previously studied benzanthrone and phosphonium dyes. The theoretical analysis of the experimental experimental FRET profiles in terms of the stretched exponential model, together with the results from the molecular docking study, provides evidence of the partial accessibility of the insulin fibril volume to the employed dyes, with the dimensionality of acceptor distribution varying from 1 to 3. The obtained results suggest that protein nanofibrils represent a promising photoluminescent material ensuring fluorophore positioning and orienting favorable for directional multistep energy transfer. Product Description popup.authors Barannik Evgen Vus Kateryna O Girnyk Serhii A. Zhitnyakivska Olga А. Tarabara Uliana K. Trusova Valeriia Mykhailivna Sheina Iryna V. popup.nrat_date 2024-01-17 Close