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Information × Registration Number 0224U001293, 0121U114420 , R & D reports Title Develop a set of measures to prevent the formation of irreversible damage to organs and systems and optimal socialization of children with rheumatic diseases popup.stage_title Head Bohmat Lyudmyla F., д.мед.н. Registration Date 19-01-2024 Organization State institution «Institute for Children and Adolescents Health Care of the National Academy of Medical Sciences of Ukraine» popup.description2 Object: indicators of quality of life, persistent disorders of the cardiovascular, respiratory systems, kidneys and liver in patients with systemic lupus erythematosus and juvenile idiopathic arthritis against the background of long-term observation and treatment. Objective: improving measures to prevent the development of irreversible organ damage and reduce the quality of life of children with JIA and SLE by controlling the activity of the disease, minimizing the manifestations of comorbid conditions and comorbidities, side effects of therapy. Methods: clinical, ultrasound, biochemical, immunological, assessment of quality of life, statistical. Results: 50.0% of children with SLE and JIA have irreversible heart damage with signs of myocardial dysfunction and maladaptive reactions to physical exertion, impaired external breathing of the restrictive type, kidney damage with reduced glomerular filtration rate, atherogenic changes in the lipid spectrum and system blood clotting The factors of their stabilization and progression are the long course of the disease with the preservation of the activity of the process. The overall level of health-related quality of life indicators in children with JIA and SLE is significantly reduced and closely related to activity indicators. With high indicators of physical and social functioning in children with JIA, the levels of emotional and school functioning turned out to be the most reduced. Novelty: it was proven for the first time that in children with SLE and JIA during long-term follow-up, persistent organ damage and metabolic disorders persist. It was established that the factors of their stabilization and progression are the long course of the disease with the preservation of immunoinflammatory activity. A significant decrease in quality of life indicators was revealed, regardless of the age of onset and duration of the disease. Efficacy: an algorithm for accompanying children with JIA and SLE was developed with the inclus Product Description popup.authors popup.nrat_date 2024-01-19 Close