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Information × Registration Number 0224U001590, 0121U111900 , R & D reports Title To study the mechanisms of inheritance of multiple sclerosis in individuals who are born of parents with this disease popup.stage_title Head Voloshyna Nataliia P., д.мед.н. Registration Date 25-01-2024 Organization State institution "Institute of Neurology, Psychiatry and Narcology, National Academy of Medical Sciences of Ukraine" popup.description2  The object of the study: patients with relapsing-remitting (RR) and progressive types of course (PTC) in sporadic and familial forms of multiple sclerosis (MS), practically healthy adult children born from parents with MS. The goal of the SRW: "To study the clinical and anamnestic and immunogenetic factors that contribute to and prevent the development of a hereditary burden to multiple sclerosis in children whose parents suffer from this disease." Research methods: anamnestic, clinical-neurological, immunogenetic, statistical-mathematical. Results of the SRW: 97 patients with MS (sporadic form – 55; familial form – 42) and 40 practically healthy adult children with burdened heredity to MS were examined. According to the anamnesis data, reliable indicators were selected, which were considered as risk factors (RF) and anti-risk factors (ARF), which contribute to and prevent the development of this disease. Reliable differences between clinical indicators in the form of various patterns revealed complex relationships between the type of course, the form of MS and the character of prognosis and testified to a more severe and unfavorable course in the familial form, in comparison with the sporadic one. Correlation analysis between clinical indicators revealed informationally different levels of organization of connections (intra-stage and inter-stage) with significant differences at all time stages of the course in two forms of MS. Based on the conducted clinical and mathematical studies, RF and ARF were selected for various variants of the prognosis, taking into account the type of course and form of the disease. Clinical anamnestic and neuroimaging studies in practically healthy adult children did not reveal specific predictors from the side of the central nervous system (CNS) and "dormant" foci of demyelination, according to magnetic resonance imaging (MRI). Product Description popup.authors Bohdanova Iryna V Vasylovskyy Vitaliy Vadymovych Voloshyn-Haponov Ivan Kostiantynovych Kiziurina Yulia Vitaliivna Kutikov Damir Oleksandrovych Kutikov Oleksandr Yevhenovych Mishina Larysa Illivna Nikishkova Iryna Mykolayivna Negreba Tetyana Valerianivna Pisotska Kseniia Olehivna Pogulyayeva Tetyana Mykolaiivna Prylepa Valentyna Oleksandrivna Chernenko Maksym Yevhenovych popup.nrat_date 2024-01-25 Close