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Information × Registration Number 0224U001660, 0123U103182 , R & D reports Title Molecular mechanisms of development of insulin resistance and restructuring of energy metabolism in metabolic syndrome popup.stage_title Head Kozlovska Mariia H., аспірант Registration Date 26-01-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2  This work describes the influence of insulin resistance and hypoxia on the state of carbohydrate and lipid metabolism, the activity of pro- and antioxidant enzymes, and the functions of isolated mitochondria. Experiments were conducted on Wistar and spontaneously hypertensive rats, in which metabolic disorders were reproduced by consuming a high-fat diet and subjected to hypoxic effects. It was shown that a high-fat diet caused insulin resistance with moderate hyperglycemia without significant disturbances in lipid metabolism. Insulin resistance led to an imbalance of pro- and antioxidant processes in mitochondria, while hypoxic preconditioning promoted the activation of antioxidant systems. Violations in the operation of the electron transport chain and a partial reversal of the protective effects of hypoxic preconditioning in insulin resistance were also observed. Hypoxic preconditioning caused favorable changes in the functional activity of mitochondria. Product Description popup.authors Zavhorodnyi Mykola O. Kozlovska Mariia H. popup.nrat_date 2024-01-26 Close