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Information × Registration Number 0224U002443, 0121U111541 , R & D reports Title Develop and substantiate a program for predicting the course of the wound process and the results of surgical treatment of deep and dermal burns to reduce the incidence of septic complications in thermal injury popup.stage_title Head Kozynets Heorhii P., д.мед.н. Registration Date 14-02-2024 Organization State Institution "Institute of Hematology and Transfusiology of the National Academy of Medical Sciences of Ukraine" popup.description2  The object of the study is patients with dermal and deep burns in the acute period of burn disease. The purpose of the work: to improve the results of treatment of victims of dermal burns by developing a diagnostic algorithm for predicting the course of the wound process, improving and rationally combining modern methods of surgical interventions, transfusion therapy schemes to reduce the risk of developing septic complications of the course of the disease in thermal trauma. Research methods: clinical, cytological, cytochemical, hematological, immunological. The developed program of surgical treatment of patients with dermal and deep burns contributes to the reduction of toxic damage to peripheral blood phagocytes, which is manifested by an increase in indicators of functional activity of neutrophil granulocytes, indicators of myeloperoxidase activity and a decrease in the content of cells with apoptotic changes in patients with burns in the stage of septicotoxemia relative to indicators of toxemia. Application of the developed algorithm for surgical treatment of burns contributed to an increase in the content of monocytes and lymphocytes in the area of ​​the wound defect, which leads to the optimization of reparative processes in the area of ​​the burn wound. There is an established tendency to optimize the functioning of monocytes. The use of the proposed treatment algorithm in complex surgical treatment leads to a decrease in the activity of reactions associated with oxidant stress, which reduces the manifestations of endothelial dysfunction, and optimization of interaction in the cascade cytokine interaction system, reduces the activity of pro-inflammatory cytokines and regulates the development of the inflammatory reaction both in the zone of thermal damage and body as a whole. Medical and social effect. Medicine. Product Description popup.authors Homola Dmytro S. Kovalenko Olha M. Кozynets Heorhii P. Lynnyk Oleksandra M. Osadcha Oksana I. popup.nrat_date 2024-02-14 Close