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Information × Registration Number 0224U002900, 0121U113837 , R & D reports Title Investigation of the combined effect of radiation and chemotherapy on genetic and metabolic changes in peripheral blood lymphocytes of patients with cervical cancer (2.2.2.445) popup.stage_title Head Domina Emiliia A., Доктор біологічних наук Registration Date 12-03-2024 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology National Academy of Sciences of Ukraine popup.description2  The characteristic features of the damage induction to the peripheral blood lymphocytes (PBL) and blood plasma of patients with cervical cancer (СС) before and after the complex treatment were determined, depending on the extent of tumor progression. A total of 36 patients with СС were examined, including 24 during or after the course of radiation or combined radiation and chemotherapy, a total of 85 observations. The average age of patients with СС was 50.5 years. In 91.2% of the examined patients, squamous cell carcinoma of the cervix was found, and in 8.8% – adenocarcinoma of the cervix. We have established that the implementation of a complex course of antitumor therapy in patients with СС, on the background of an increased level of oxidative metabolism, DNA damage and apoptosis of PBL, leads to an increase in the duration of oxidative stress and violations of the pro-antioxidant balance, which were present in the blood of patients with СС. The expressiveness of redox balance disorders in patients with CC depended on the degree of tumor progression, which is a precondition for the development of early and long-term side effects in healthy cells and tissues. Product Description popup.authors Hlavin Oleksii A. Dumanskyi Yurii V. Kondrashova Halyna H. Makovetska Liudmyla I. Mikhailenko Viktor M. Prokopenko Ihor V. popup.nrat_date 2024-03-12 Close