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Information × Registration Number 0224U002952, 0121U110084 , R & D reports Title To study the effectiveness of organ-preserving surgical tactics for the treatment of kidney cancer, to optimize the indications and medical rehabilitation of patients. popup.stage_title Head Stakhovsky Eduard O., Доктор медичних наук Registration Date 18-03-2024 Organization National Cancer Institute popup.description2 The object of the study is patients with renal cell cancer. The goal of the work is to increase the effectiveness of treatment and reduce the disability of patients with NKR by optimizing the indications for organ-sparing operations and unifying the principles of medical rehabilitation. Research methods: clinical, laboratory, radiation, pathomorphological, statistical. On the basis of a prospective non-randomized study evaluating the impact of central and local thermal ischemia on the functional state of the kidney during resection based on dynamic renoscintigraphy, which included 557 patients with localized NCR, it was found that the size of NCR did not affect the choice of central or local thermal ischemia. Nephrometric indicators that indicated the placement of NKR closer to the renal portal (p<0.05) and a smaller volume of functioning kidney parenchyma (p<0.001) are the main parameters that influenced the choice of surgeons in favor of central thermal ischemia for the purpose of better visualization and adequate control of hemostasis. It was established that kidney resection with central thermal ischemia leads to irreversible changes in the parenchyma and a significant progressive decrease in both the total glomerular filtration rate by 10% and the glomerular filtration rate on the affected side by 23.2% (p<0.05). Local ischemia does not cause a significant decrease in the filtration function of the kidneys. The use of the multimodal program "Fast-Track Surgery" during kidney resection is complemented by the refusal of central thermal ischemia of the kidney, the restoration of the integrity of the kidney parenchyma with a double-row suture, the refusal of drainage of the retroperitoneal space and the early activation of patients, which allows reducing the postoperative bed-day to 3.5 ( p<0.001) with a similar level of perioperative complications (x2 = 0.67; p = 0.41). Product Description popup.authors Vitruk Yurii V. Voilenko Oleh A. Kononenko Oleksii A. Stakhovskyi Oleksandr E. popup.nrat_date 2024-03-18 Close