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Information × Registration Number 0224U031654, 0122U001909 , R & D reports Title Pathology of the joints, caused by metabolic disorders in the post-hepatic period popup.stage_title Head Savchuk Oleksii M., Доктор біологічних наук Registration Date 30-05-2024 Organization Taras Shevchenko National University of Kyiv popup.description2 For the first time, a comprehensive study of biochemical indicators of the degree of local and systemic inflammation, processes of free radical oxidation, angiogenesis and hypoxic state, the system of hemostasis, the intensity of expression of genes involved in the development of joint pathology, in the blood and synovial fluid of patients with OA who suffered from SARS-CoV-2 was carried out an infection It was shown that in patients with OA, after a long post-COVID-19 period, there was an increase in the plasma level of IL-1β and a decrease in the level of TNF-α and NF-κB compared to controls, the content of the products of oxidative modification of proteins increased and the content of sulfhydryl groups in the synovial fluid decreased and blood plasma of osteoarthritis patients who recovered from COVID-19 compared to the osteoarthritis group. A decrease in the level of the stress protein HSP60 was found in the blood of patients with OA, as well as those who had SARS-CoV-2 infection. Systemic deregulation of the cytokine profile was accompanied by a decrease in the plasma levels of proangiogenic growth factors, most pronounced in cases of VEGF and PDGF. This analysis did not reveal significant changes compared to the control in the level of the hypoxic transcription factor HIF-1α in the plasma of the experimental groups of patients. Against the background of an imbalance in the procoagulant link of hemostasis, there was a suppression of functioning and a decrease in the content of natural anticoagulants - protein C, antithrombin III and thrombomodulin; suppression of the fibrinolysis system, which was expressed in a decrease in the concentration of plasminogen, its tissue activator tPA, PAI-1 inhibitor and alpha-2-antiplasmin activity; an abnormal level of proteinase inhibitors alpha 1-antitrypsin and alpha 2-macroglobulin was observed. Product Description popup.authors Halenova Tetiana I. Dvorshchenko Kateryna O. Koval Tetiana V. Krenytska Daryna I. Rachkovska Antonina M. Falalieieva Tetiana M. popup.nrat_date 2024-05-30 Close