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Information × Registration Number 0224U032214, 0118U007343 , R & D reports Title Molecular, genetic and pharmacological agents of influence on cellular mechanisms of neurological disorders. popup.stage_title Head Kryshtal Oleh О., д.б.н. Registration Date 14-08-2024 Organization Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine popup.description2 Blocking the activity of proton-sodium ion exchangers (Na+/H+-exchangers) enhances the proton-induced nociceptive response of afferent skin fibers. Based on the screening of the activity of 11 novel compounds, three effective modulators of GABA receptor activity were identified, one of which shows potential antiepileptic effects. Cannabidiol has antiseizure action in in vitro models of epilepsy, and the potency of its effects depends on the mechanism of pathological synchronization of neural networks. Methylene blue inhibits the activity of ATP-dependent potassium channels. Intravenous administration of stem cells contributes to the reduction of spasticity in the hind ipsilateral limb of mice of different sexes after spinal cord injury modeling, particularly effective during the first month. The newly synthesized fullerene-based compaund K400 reduces contractile responses of mouse colonic smooth muscle to KCl solution, indicating partial blocking of calcium potential-dependent channels by nanoparticles; at the same time, K400 does not affect carbachol-induced contractions, thus having no effect on TRPC4 channels. Using the patch-clamp method in "excised patch" or "nucleus attached" configurations, the impact of divalent metal ions on LCC channels of the nuclear membrane of Purkinje cerebellar neurons was investigated. The actin cytoskeleton in the form of G-actin regulates the accessibility of procaspase-9 for the formation of the apoptosome, and in the form of F-actin, it serves as a buffer for XIAP/IAP proteins, which sequester activated caspase-3 during apoptosis induction. For the first time, data suggesting the potential effectiveness of green tea catechins against the Omicron variant of SARS-CoV-2 and its subvariants have been obtained. Product Description popup.authors Isaiev Dmytro S. Dryn Dariia O. Kotliarova Anna-Malhozhata B. Maksymiuk Oleksandr P. Melnyk Mariia I. Prudnikov Ihor M. Rybachuk Oksana А. Storozhuk Maksym V. Cherninskyi Andrii O. Chyzhmakov Ihor V. popup.nrat_date 2024-08-14 Close