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Information × Registration Number 0224U032531, (0119U002238) , R & D reports Title Scientific and methodological ways to improve the availability, quality and effectiveness of specialized care population of regions (administrative regions) in terms of managerial autonomy and financial activities providers of medical services popup.stage_title Розробка наукових основ біотехнології ліпосомальних наночасток з гідрофобними антиоксидантами та вивчення їх фармаколлогічної і терапевтичної активності в хіміотерапії злоякісних пухлин Head Dudnichenko Oleksandr S., д.мед.н., професор Registration Date 12-11-2024 Organization Kharkiv National Medical University popup.description1 popup.description2  Carried out: a review of the literature, a comparative analysis of the toxicity of liposomal forms of antioxidants curcumin, quercetin, ubiquinone and individual lipids included in the study liposomal compositions in the experiment; the composition and technology of the complex liposomal composition of hydrophobic antioxidants based on curcumin and quercetin were chosen; received product drug), stable for 12 months. It was established: the presence of antioxidant activity of liposomal forms of curcumin, quercetin and ubiquinone; pharmacological activity in vivo of a complex hyposomal composition of hydrophobic antioxidants containing curcumin and quercetin against lipid peroxidation products of biological membranes in a model of coronary heart disease in rats, and the synergistic effect of quercetin and curcumin was confirmed. It has been proven: the effectiveness of the complex application of hydrophobic antioxidants acting on different links of the antioxidant system for the prevention of general toxicity of antitumor cytostatic drugs in the clinic in cancer patients. Product Description popup.authors Biletskyi Volodymyr Ye. Kasianova Anna V. Khilchevskyi Bohdan S. popup.nrat_date 2024-11-12 Close