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0224U033076,
(0124U003418)
,
Combo treatment with radiation and targeted therapy to defeat tumor radioresistance
Ідентифікація молекулярних шляхів, пов’язаних із CSC, що мають відношення до відповіді клітин GBM та PCa, отриманих від пацієнтав, на протонну та фотонну променеву терапію.
Telegeev Gennadii D., Доктор біологічних наук
17-12-2024
Institute of Molecular Biology and Genetics of NAS of Ukraine
this project aims to identify gene signatures and mechanisms associated with high tumor radioresistance to PT and PBT and worse clinical outcomes of the patients with PCa and GBM treated with radiotherapy and to develop novel approaches for tumor radiosensitization. The results of this project, in the long perspective, might help develop novel clinically relevant biomarkers and radiosensitizers for different types of solid tumors.
The relative expression of Syncytin 1, Syncytin 2, Syncytin 1 (unspliced), Syncytin 2 (unspliced), ALDH1A3, MMP2, MMP9 genes in PC3 Mix cells after irradiation with photon irradiation was investigated. Some interesting trends were described, including a decrease in the expression of ALDH1A3, Syncytin1 and Syncytin 2 genes in response to cultivation with the glioblastoma chemotherapy agent temozolomide; assessment of their statistical significance requires further biological reproductions. It has been shown that photon radiotherapy can affect the expression of the genes CTPS1, TRIO, DDB2 in DU145 cells, although this effect is insignificant and does not exceed 25%. Photon radiotherapy revealed a decrease in TRIO gene expression at 2 Gy, an increase in DDB2 expression at 6 Gy, and an increase in CTPS1 expression at 4 Gy and 6 Gy. Proton radiotherapy changes the expression of CTPS1, TRIO, DDB2 genes. Although these changes are quite insignificant, it should be noted that the increase in CTPS1 expression was proportionally correlated with the increase in radiation level and may be promising for further in-depth study.
Anopriienko Olha V.
Antonenko Svitlana V.
2024-12-17
Updated: 2025-12-24
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