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Information × Registration Number 0225U000015, (0120U100309) , R & D reports Title Directed synthesis of novel nitrogen- and oxygencontaining heterocyclic compounds as low molecular weight bioregulators. popup.stage_title Модифікація нітроген- і оксигенвмісних гетероциклів фармакофорними групами з метою покращення корисних біологічних властивостей. Head Brovarets Volodymyr S., Доктор хімічних наук Registration Date 02-01-2025 Organization V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the National Academy of Sciences of Ukraine popup.description1 Development of preparative methods to obtaine new nitrogen and oxygen-containing heterocyclic compounds and their chemical and biological properties investigation. popup.description2 Effective and simple protocols have been developed for the construction of new nitrogen- and oxygen-containing heterocyclic compounds: sulfones of the dihydroimidazopyrimidinone and tetrahydropyrimidopyrimidinone series, imidazoles, 2,4,5-trisubstituted oxazoles, 1,3-oxazoles containing an oxiran-2-yl ring in the second position, 5-amino-1,3-oxazol-4-yl(triphenyl)-phosphonium salts containing a hydroxyalkylamino group in the fifth position, peptidomimetics − derivatives of phosphorylated glycine containing alkyl halide and alkyl thiocyanate residues, 1,2-dihydrophthalazines, 3 (hetaryl/aryl)-aminoisoquinolin-1(2H)-ones, pyrazole-containing aurones, 3-trifluoromethylpyrazole-deoxybenzoins, and 5H-imidazo[1,2-e][1,3,5]triazepines. The compounds were found to be active against cytomegalovirus, HPV and papillomavirus. A number of new biologically active 4-(dichloromethyl)pyrazolo[1,5-a][1,3,5]triazines and [1,3]oxazolo[4,5-d]pyrimidines were obtained for the first time. Their electronic structure and spectral properties were studied. The compounds showed high antitumor and antiviral activity. The influence of the nature of the substituents in different positions of the heterocycles on the level of biological activity was studied. A strategy for developing a high-throughput fluorescence-polarization analysis for the creation of new biologically active compounds for the treatment of diseases associated with glycogen accumulation is described. Product Description popup.authors Іvanova Іryna V. Bahrieieva Oksana S. Bodachivskyi Yurii S. Brusnakov Mykhailo Yu. Vydzhak Roman M. Herasymov Yehor S. Holovchenko Oleksandr V. Demydchuk Bohdan A. Zhyrnov Viktor V. Zaporozhets Dmytro V. Ziabriev Volodymyr S. Kachaieva Maryna V. Kachkovskyi Oleksii D. Kozachenko Oleksandr P. Konovalenko Artem S. Kornii Yurii Ye. Losʹ Oleksandr V. Liutenko Nataliia V. Mitiukhin Оleh P. Malets Yehor S. Myshko Andrii S. Moskvina Viktoriia S. Mruh Halyna P. Pilo Stepan Hr. Panchyshyn Svitlana Ya. Porkhun Svitlana V. Potikha Liudmyla M. Prokopenko Volodymyr M. Prostota Yaroslav O. Rayenko Yevhen H. Rybakova Antonina V. Severin Oleksandr O. Synenko Vitalii O. Solomiannyi Roman M. Frasyniuk Mykhaylo S. Chumachenko Svitlana A. Shablykin Oleh V. Shablykina Olha V. popup.nrat_date 2025-01-02 Close