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Information × Registration Number 0225U000079, (0124U000540) , R & D reports Title Development of osteoconductive materials with improved osteoregenerative and antimicrobial potential for the restoration of bone tissue popup.stage_title Синтез композитів гідроксиапатит-нанометали-фітоекстракти та вивчення антибактеріальної дії відносно полірезистентних штамів Head Holubnycha Viktoriia М., Кандидат медичних наук Registration Date 04-01-2025 Organization Sumy State University popup.description1 To increase the efficiency of bone defects replacing by developing an original composite based on hydroxyapatite-nanometals-phytoextracts, and establishing the dynamics of regenerative process of an experimental defect infected with multiresistant microorganisms, when applied synthesized composite popup.description2  A method for preparation of the composite materials based on hydroxyapatite modified with metal nanoparticles and phytoextracts of comfrey, calendula, and pomegranate was elaborated. The integration of nanoparticles and phytoextracts into freshly synthesized hydroxyapatite was proposed, enhancing its sorption properties due to the developed surface area of the nanoparticles. Aqueous and alcoholic solutions of phytoextracts were incorporated into the composites. Composite materials contained precise concentrations of copper (250, 500, and 1000 µg/g), silver (25, 50, 75, 100 µg/g), zinc oxide (1000 µg/g), and phytoextracts of comfrey, calendula, and pomegranate. The physicochemical characteristics of the resulting materials were characterized using scanning electron microscopy, EDX analysis, zeta potential measurements, sorption property analysis, FTIR, and ASAP techniques. The antimicrobial activity of the hydroxyapatite-metal nanoparticles-phytoextract composite materials was analyzed against clinical multidrug-resistant strains of microorganisms causing wound infections. Antimicrobial activity was observed in composites containing copper and silver nanoparticles against the studied microorganisms. Intrinsic antimicrobial activity was identified only in the pomegranate phytoextracts. Synergistic antimicrobial activity was noted when nanoparticles and phytoextracts were used simultaneously, resulting in several fold decreasing of effective concentrations of nanoparticles. The adsorption and desorption characteristics of nanoparticles and phytoextracts when combined with hydroxyapatite were studied. The desorption rates depended on the initial concentrations of nanoparticles, the chemical properties of the phytoextract components (phenols, flavonoids, alkaloids, etc.), the physicochemical characteristics of the composite (porosity, surface charge, hydrophilicity), and environmental conditions (pH, temperature, ionic strength) Product Description popup.authors Antonova Hanna O. Holubnycha Viktoriia М. Derevianko Tamara V. Korenkov Oleksii V. Myronov Petro F. Pelekh Yehor D. Pshenychnyi Roman M. Tveresovska Olesia І. Yanovska Hanna O. popup.nrat_date 2025-01-04 Close