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Information × Registration Number 0225U000158, (0122U202078) , R & D reports Title Analysis of the course and complications of pharmacotherapy of ankylosing spondylitis and systemic lupus erythematosus depending on treatment programs in conditions of post-traumatic stress disorder. popup.stage_title Завершення обстеження хворих та формування електронної бази даних. Проведення імунологічних досліджень. Оцінка та оптимізація програм лікування та профілактики остеопорозу при системних захворюваннях. Вивчення культуральних і функціональних властивостей мультипотентних стромальних клітин у хворих на системний червоний вовчак. Head Havrylenko Tetiana I., д.б.н.Kovalenko Volodymyr M., Доктор медичних наукNikolskyi Ihor S., д.мед.н. Registration Date 06-01-2025 Organization State Institution "National Scientific Center "Institute of Cardiology, clinical and regenerative medicine named after academician M.D. Strazhesko" of the National Academy of Medical Sciences of Ukraine popup.description1 To conduct an analysis of various treatment programs of ankylosing spondylitis and systemic lupus erythematosus based on a comprehensive study of the clinical features of disease and laboratory markers of inflammatory process activity, to develope new approaches to differentiated treatment, including the use of cell therapy methods. popup.description2 Object: Ankylosing spondyloarthritis (AxSpA) and systemic lupus erythematosus (SLE). Research Objective: To analyze various treatment programs and investigate potential laboratory markers for ankylosing spondyloarthritis (AxSpA) and systemic lupus erythematosus (SLE), study the properties of adipose tissue mesenchymal stem cells (MSCs) in patients with SLE and AxSpA, and evaluate the effects of lipopolysaccharide (LPS) and dexamethasone on their activity. Methods of Study: Clinical; Laboratory studies: endothelin-1 (ET-1), ferritin, interleukin-2, serum amyloid A (SAA), cortisol, leptin, and antinuclear antibodies; Radiological: cervical and lumbar spine and sacroiliac joints X-ray; Cultural; Statistical: Data analysis using Statistica 10.0 and R-studio. Results. Osteoproliferative changes (syndesmophytes) in AxSpA have been found to be associated with decreased BMD. Reduced BMD and osteoproliferative changes share common risk factors: the activity and duration of AS, smoking, and the use of glucocorticoids. It was established, that in patients with AxSpA, weight gain of 1 kg resulted in a less pronounced increase in leptin concentration compared to the control group. Cortisol level in AxSpA patients did not significantly differ from the control group, was not associated with disease activity, and therefore cannot be used as a laboratory marker for AxSpA. Mycophenolate mofetil demonstrated the best efficacy and safety profile in SLE, making it a priority treatment option for patients with a significant comorbid background. Markers of high SLE activity were identified as: SAA levels above 35.75 mg/L (sensitivity 83.3%; specificity 68.8%), ET-1 levels above 4.14 pg/mL (sensitivity 58.3%; specificity 85.7%). The growth kinetics of adipose tissue MSCs in patients with SLE and AxSpA were significantly slowed. While LPS substantially stimulated growth, dexamethasone had no effect on growth kinetics but demonstrated the ability to negate the effect of LPS. Product Description popup.authors Biliavska Yuliia V. Bortkevych Oleh P. Havrylenko Tetiana I. Harmish Olena O. Dubas Vitalli V. Kovalenko Volodymyr M. Kovalenko Serhii O. Kucherenko Danylo O. Lichman Oleksandr M. Levchenko Volodymyr H. Nikolska Valentyna V. Nikolskyi Ihor S. Pidhaina Olena A. Pasternak Marta L. Protsenko Halyna O. Romanovskyi Andrii V. Semenova Yana-Mariia O. Semeniako Larysa K. Sytenko Anastasiia O. Talaieva Tetiana V. Taranukha Liubov I. popup.nrat_date 2025-01-06 Close