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Information × Registration Number 0225U000365, (0124U003838) , R & D reports Title Flow chemistry as an advanced approach for scale up of hazardous processes popup.stage_title Створення наукових та технологічних основ для розробки проточних реакторів з метою безпечного використання агресивних нестійких реагентів в масштабованому органічному синтезі на прикладі адаптації застосування металоорганічних сполук. Head Volochnyuk Dmytro M., Доктор хімічних наук Registration Date 10-01-2025 Organization Institute of Organic Chemistry NAS of Ukraine popup.description1 The main goal of the project is to create a scientific and technological basis for the development of flow reactors for the safe use of aggressive unstable reagents in large-scale organic synthesis. The use of organometallic compounds will be representative case. The demonstration pros and cons of the proposed approach compared to batch reactors is another valuable goal of the project as well as applying of the developed technology to other dangerous processes and reagents. popup.description2  The widespread use of organometallic reagents in industry is limited by their sensitivity to atmospheric oxygen and moisture and the risk of ignition of the reagent and/or solvent. Synthesis of such compounds in a flow-through mode allows generating and operating with only a small amount of solution of such reagents, and, therefore, avoiding dangerous incidents when working with them. During the reporting period, a flow-through unit for the synthesis and further transformations of organometallic compounds was designed and assembled based on domestic equipment. The conditions for lithiation of aromatic and heteroaromatic substrates were optimized. Formylation, carboxylation, and synthesis of organometallic and tin compounds were carried out on the basis of the obtained organolithium semiproducts. In particular, as a result, a library of heterocyclic substituted boronic acids was prepared. A flow reactor for the synthesis of organozinc compounds was created and launched. The effect of temperature, solvent nature, and the presence of inorganic salts on the stability of solutions of organozinc products was investigated. Using chemoinformatics methods, about 100 promising objects for semi-industrial metallation using the developed flow technologies were selected. In continuation of the development of multigram synthesis processes based on the hazardous reagent diazomethane, simple approaches to the preparative synthesis of substituted cyclopropanes, valuable intermediates for pharmaceutical chemistry and agrochemistry, were developed. They were synthesized by the interaction of diazomethane with methyl acrylates and photoinduced nitrogen removal from the formed Δ1-pyrazolines in a flow photoreactor. A protocol was developed for the scalable diastereoselective synthesis of cyclopropanols by oxidative hydrolysis of cyclopropylboron pinacolates. The protocol for Pd-catalyzed cyclopropanation of vinylboron pinacolates was adapted for the flow regime, which provides safe ope Product Description popup.authors Andrushko Olesandr P. Oleksandr V. Borysov Demchuk Oleksandr P. Dmytriv Yurii V. Druzhenko Tetiana V. Pendiukh V'iacheslav V. Sham Vadym A. Yakovleva Hanna V. popup.nrat_date 2025-01-10 Close