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Information × Registration Number 0225U000432, (0122U000424) , R & D reports Title To study the pathogenetic and molecular mechanisms of spermatogenesis disorders in male infertility. popup.stage_title Вивичити патогенез та молекулярні механізми порушень сперматогенезу при чоловічій неплідності Head Romanenko Alina M., д.мед.н. Registration Date 11-01-2025 Organization State Institution "Academician O.F. Vozianov Institute of Urology of the National Academy of Medical Sciences of Ukraine" popup.description1 To study the pathogenetic and molecular mechanisms of spermatogenesis disorders and the state of the hematotesticular genesis of the barrier in various forms of male infertility with the study of histological and immunochemical features of the pathology. popup.description2  Purpose of the work. To investigate the pathogenetic and molecular mechanisms of spermatogenesis disorders and the state of the hematotesticular barrier in various forms of male infertility by studying histological and immunohistochemical and pathological features. Structural changes in the testis were determined and molecular and epigenetic mechanisms underlying spermatogenesis disorders were elucidated: activation of ubiquitination and sumoylation processes, which leads to enhanced post-translational modification of proteins, enhanced degradation by ubiquitination of hematotesticular barrier proteins Occludin and Claudin 11, disruption of the regulatory effect of TGF-beta on spermatogenic epithelial cells and Leydig cells. The impact of small doses of ionizing radiation, as an additional etiological factor, leads to changes in the interstitial, vascular and endocrine components of the testicle, as well as molecular, including epigenetic changes, which can be characterized as an ecological pathomorphosis of male infertility, which leads to disorders of spermatogenesis and increases the risk of initiation of carcinogenesis. A scheme of pathogenetic mechanisms of disorders of spermatogenesis, ecological pathomorphosis of male infertility and possible initiation of carcinogenesis in the testis under the influence of ionizing radiation has been developed. Product Description popup.authors Bazalytska Svitlana V. Voronchuk Nina P. Liakhno Taras M. Nehrei Larysa M. Romanenko Alina M. Sakalo Anatolii V. Senchenko Nadiia M. Cheremukha Serhii V. Cherniak Ivanna L. popup.nrat_date 2025-01-11 Close