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Information × Registration Number 0225U000572, (0120U105394) , R & D reports Title Mechanisms of formation of changes in the central nervous system after exposure to extreme factors popup.stage_title розробка способу моделювання травми головного мозку, вивчення патофізіологічних та структурних змін ЦНС у динаміці після дії екстремального фактору. Head Koldunov Viktor V., д.мед.н. Registration Date 14-01-2025 Organization Dnipro State Medical University popup.description1 to establish the links of the pathogenesis of damage to the central nervous system after the action by extreme factors, including baro-acoustic factor popup.description2  The research allowed us to expand and substantiate the mechanisms of primary and secondary brain damage. It was found that the behavior of rats with BINT has periods of excitement and anxiety, lack of fear (anxiolytic), which turn into a state similar to depression. It is also important that BINT results in impaired spatial and associative memory, which is not significantly restored. These changes depend on the primary effect of the blast wave, which leads to mitochondrial damage that triggers pathobiochemical processes, namely, an imbalance of biometals and oxidative stress with subsequent energy deficit, which contributes to the activation of secondary damage through a vicious circle and leads to neuronal excitation, as indicated by anxiety and a decrease in the pain threshold of experimental animals. BBB disruption leads to ischemia and hypoxia, which aggravates oxidative stress and energy deficit, and promotes the development of edema of neurons, their organelles and processes, which impairs the generation and transmission of nerve impulses. In addition, in response to brain damage, neurotrophic factor is activated, the neuroprotective effect of which was established by the presence of an anxiolytic period. Subsequently, compensatory mechanisms are depleted, biometal imbalances indicate the persistence of metabolic disorders, and injured animals enter a state similar to depression. Based on the results of biometals changes, it was found that in the forebrain, due to significant changes in biometal homeostasis, pathobiochemical processes were more pronounced compared to the cerebellum, indicating the importance of taking into account the position of the animal to the source of the blast wave. Product Description popup.authors Klopotskyi Heorhii A. Kozlova Yuliia V. Koldunov Viktor V. Triasak Nataliia S. Chaban Vladyslav O. popup.nrat_date 2025-01-14 Close