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Information × Registration Number 0225U000832, (0123U100629) , R & D reports Title Development of immunobiological means of diagnosis and new approaches to the treatment and prevention of P. aeruginosa infection in conditions of martial law popup.stage_title Розробка імунобіологічних засобів діагностики та нових підходів до лікування і профілактики синьогнійної інфекції в умовах воєнного стану Head Derkach Svitlana A., к.мед.н. Registration Date 20-01-2025 Organization State Institution "I. Mechnikov Institute of Microbiology and Immunology National Academy of Medical Sciences of Ukraine" popup.description1 Increasing the effectiveness of prevention and treatment of nosocomial infections in the conditions of martial law through the use of developed diagnostics and autovaccines popup.description2  The study of 5 samples of multi-strain vaccines from nosocomial strains of P. aeruginosa obtained by photodynamic method has been conducted. Their protective activity and effectiveness in autovaccinotherapy have been demonstrated. The use of a developed model of pseudomonas infection, dominated by local manifestations of the inflammatory process with a prolonged course, allowed for the experimental confirmation of the effectiveness of autovaccinotherapy in wound injuries. It was shown that the healing of infectious wounds using the vaccines occurred twice as fast and without septic complications compared to untreated animals. The presence of positive seroconversion of specific antibodies to Pseudomonas aeruginosa in vaccinated animals was experimentally confirmed. It was shown that, for the selection of individuals from at-risk groups for preventive immunization, it is advisable to preliminarily determine not only the titer of specific antibodies but also the level of interleukin-17 secretion by blood leukocytes. The most promising method in this context is the use of real-time PCR. The implementation of the obtained results may contribute to reducing morbidity and mortality rates, occurrence of complications in combat injuries, and decreasing the in-hospital circulation of multidrug-resistant pathogen strains. Product Description popup.authors Derkach Svitlana A. Diachenko Valentyna F. Kutsai Nataliia M. Makarenko Valentyna D. Mariushсhenko Anatolii M. popup.nrat_date 2025-01-20 Close