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Information × Registration Number 0225U000909, (0123U100689) , R & D reports Title To develop a microbiome-oriented strategy against the progression of nonalcoholic fatty liver disease under the influence of wartime stress and its consequences popup.stage_title Розробити мікробіом-орієнтовану стратегію проти прогресування неалкогольної жирової хвороби печінки під впливом стресу воєнного часу та його наслідків. Head Fadieienko Halyna D., Доктор медичних наук Registration Date 21-01-2025 Organization Government Institution "L.T.Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine" popup.description1 To study the influence of intestinal microbiota on the course of non-alcoholic fatty liver disease (NAFLD) under conditions of chronic stress and, to develop pathogenetic-based treatment and measures to prevent the progression of the disease popup.description2  Patients with nonalcoholic fatty liver disease (NAFLD) were examined during the war in comparison with patients with NAFLD who were examined in the pre-war period, as well as individuals from a control group of the appropriate age and sex. Research methods: questionnaire; determination of biomarkers of chronic stress (dehydroepiandrosterone, prolactin, brain-derived neurotrophic factor, profile of markers of systemic inflammation and mitochondrial damage by sirtuin level by enzyme-linked immunosorbent assay, qualitative and quantitative composition of intestinal microbiota at the level of main phyla and butyrate metabolism (by the level of butyrate-producing bacteria) by real-time polymerase chain reaction. The main epigenetic factors that could potentially influence the course of NAFLD during the war were identified and assessed. The most significant manifestations were psychoemotional disorders in the form of astheno-neurotic and anxiety-depressive disorders, disturbances in the diet and quality of nutrition. In patients with NAFLD who were exposed to stress factors of the war period, a significant imbalance of the intestinal microbiota was observed, which was manifested by an increase in the content of Firmicutes and a decrease in the pool of Bacteroidetes. The association between the degree of disruption of the integrity of the epithelial intestinal barrier, state of intestinal microbiota and stress hormones in patients with NAFLD during wartime. Based on the data obtained, a set of preventive measures was developed aimed at inhibiting the development of inflammation and fibrosis processes in liver tissue in patients with NAFLD by correcting the microbiota and modifying the stress factors of wartime. Product Description popup.authors Yemelianov Dmytro V. Bondar Tetiana M. Buriakovska Olena O. Volobuieva Vira P. Halchynska Valentyna Yu. Hridniev Oleksii Ye. Kostiuk Olena I. Kurinna Olena H. Kushnir Inna E. Nikiforova Yana V. Riabovol Inna S. Solomentseva Tetiana A. Stepanova Olha V. Trybushkina Iryna M. Fadieienko Halyna D. Chereliuk Nataliia I. Chernova Valentyna M. Shut Inna V. popup.nrat_date 2025-01-21 Close