Search academic texts

Information × Registration Number 0225U001130, (0123U101652) , R & D reports Title Research on ways to overcome antibiotic resistance of opportunistic pathogens in patients with oncohematological pathology popup.stage_title Визначити мінімальні інгібуючі концентрації антибіотиків та спектр умовно-патогенних мікроорганізмів, у яких відновлюється чутливість до антибактеріальних препаратів. Head Rybalska Alla P., д.б.н. Registration Date 26-01-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 Determine ways to minimize antibiotic resistance of the main pathogens of infectious and inflammatory complications in patients with acute and chronic leukemia popup.description2  Object – 231 strains of bacteria and yeasts, 55 antibiotic drugs (ABD) of various classification groups, 8 antimycotics. Methods – hematological, microbiological, immunological, statistical. Purpose – determine ways of minimizing antibiotic resistance of the main causes of infectious-inflammatory complications in patients with acute and chronic leukemia. 231 strains of bacterial and fungal cultures were observed and identified from the biotopes of the upper respiratory tract (URT). In 1975, a study was conducted to determine the antibiotic sensitivity of 87 strains of intellectually pathogenic microorganisms, from the selection of antibiotic and antimycotic panels with the regulation of EUCAST 2021. It was established that the use of The component probiotic drug indirectly has a positive impact on the microecology of the URT of 87,5% of patients for the year: elimination of viral causes of infectious complications - representatives of the genus Micrococcus, Corynebacterium, Moraxella, Enterococcus, Klebsiella; decreased titer of Enterococcus sp., S.aureus, S.saprophyticus, Corynebacterium sp., Moraxella sp.; identification of “hidden pathogens” S.saprophyticus, S.epidermidis, Corynebacterium sp., Enterococcus sp., Klebsiella sp. A positive influence of a multicomponent probiotic preparation on the microbiome of URT was revealed in 50,0% of patients for the rate of elimination of Enterococcus sp., Moraxella sp. and the appearance of “hidden pathogens”. Against the background of the stagnation of probiotics, the strains S.aureus and S.epidermidis are able to synthesize aggressive enzymes. The application of probiotics in the suppository therapy of patients is associated with an increase in the index of completion of phagocytosis and a decrease in the local function of peripheral neutrophil granulocytes. Medical and social effect. Medicine. Product Description popup.authors Horiainova Nadiia V. Kyselova Olena A. Melnyk Olena A. Nemyrovska Liudmyla M. Skachkova Nadiia K. popup.nrat_date 2025-01-26 Close