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Information × Registration Number 0225U001230, (0122U000420) , R & D reports Title To study the state of the growth hormone/growth factor system in children and adolescents with endocrine pathology depending on the supply of vitamin D and variants of its receptor gene polymorphism popup.stage_title Вивчити стан системи гормон росту/ростові фактори у дітей та підлітків з ендокринною патологію в залежності від забезпеченості вітаміном D і варіантів поліморфізму гена його рецептора. Head Bolshova Olena V., Доктор медичних наук Registration Date 28-01-2025 Organization State Institute "V.P. Komissarenko Institute Of Endocrinology And Metabolism of The National Academy of Medical Science of Ukraine" popup.description1 To develop recommendations for hormonal and metabolic correction of disorders in the growth hormone / growth factors system, growth rates and optimal monitoring of children and adolescents with short stature, type 1 diabetes, obesity associated with hypothalamic dysfunction, depending on the vitamin D supply and variants of its gene receptor polymorphism. popup.description2 The majority of children with growth retardation 90,44 % were found to have hypovitaminosis D. A significant relationship between the GH/IGF-1 axis and the level of vit D was found - the greater the hypovitaminosis D, the stronger the dependence of the indicators. The risk of developing GHD is significantly increased in the presence of heterozygous polymorphisms of the VDR gene BsmI GA; TagI TC; ApaI CA. Carrying the allele A of the locus rs1544410 BsmI, the pathological allele C of the locus rs731236 TaqI of the VDR gene is significantly associated with the risk of developing ISS. The risk of developing SBNGH is significantly increased in the presence of homozygous pathological polymorphisms of the VDR gene. In the presence of the pathological variant AA of the BsmI polymorphism of the VDR gene, the risk of SGA significantly increases. In 86 % of obese children with hypothalamic dysfunction, hypovitaminosis D was found. The most significant changes in lipid fractions were observed in patients with stage III obesity, who had the lowest content of 25OHD in the blood; a significant decrease in the content of vit D is associated with a significant increase in the level of PTH. An increase in the HOMA-IR index is observed in parallel with the increase in vit D deficiency. The level of VD-BG has a positive correlation with the level of 25(OH)D and is negatively associated with BMI. In children with type 1 diabetes, vit D deficiency was found in 51,9 % of children, vit D insufficiency – in 35,6 % of children. The presence of hypovitaminosis D in most patients with short stature, type 1 diabetes, and obesity on the background of HD necessitates the need to consider the serum 25OHD content in the diagnosis, treatment, and monitoring of such patients, and to take appropriate preventive measures to correct dyslipidemia. It has been proven that the addition of vitamin D preparations leads to an increase in the effectiveness of treatment of patients with short stature. Product Description popup.authors Bolshova Olena V. Vyshnevska Olha A. Kvacheniuk Dmytro A. Lukashuk Iryna V. Malinovska Tetiana M. Pakhomova Viktoriia H. Ryznychuk Mariana O. Samson Oksana Ya. Sprynchuk Natalia A. popup.nrat_date 2025-01-28 Close