Search academic texts

Information × Registration Number 0225U002421, (0122U001492) , R & D reports Title To study the effectiveness of immunocorrection in the treatment of ischemic optic neuropathy popup.stage_title Вивчити ефективність імунокорекції в лікуванні ішемічної невропатії зорового нерва Head Zborovska Oleksandra V., Доктор медичних наук Registration Date 10-03-2025 Organization VP Filatov Institute of Ophthalmology and Tissue Therapy of the National Academy of Medical Sciences of Ukraine popup.description1 To study the features of pathogenesis, clinic, development of methods of prevention and determination of the effectiveness of antiplatelet drugs and immunocorrection in the treatment of ischemic optic neuropathy and inflammatory eye diseases popup.description2  To determine the characteristics of the immune status and ocular blood supply and compare the volumetric pulse blood supply of the eye using rheoophthalmography in patients with optic neuritis and its consequences, as well as in anterior ischemic neuropathy (in acute and chronic disease courses)Results. Ocular Hemodynamics: Expanded knowledge about hemodynamic changes in ischemic neuropathy. Suggested the use of RQ, V (Ohm/s), and α1/T (%) indicators for differential diagnosis of optic neuropathy. The cutoff value for V (0.9 ‰) was established, with sensitivity (67%) and specificity (55%). Immune Status: Enhanced data on the expression of molecular markers CD 5, CD 25, and CD 54 in ischemic neuropathy and inflammatory diseases of the vascular tract. COVID-19: Identified clinical, hemodynamic, immune, and structural changes in the optic nerve during optic neuropathy complicated by COVID-19. Receptor Expression: Demonstrated, for the first time, that the expression level of adrenergic and acetylcholine receptors increases significantly (by 12.6–31.7%) during posterior uveitis inflammation. Immune Response: Established that in acute ischemic optic neuropathy, IgM levels are 3.5 times lower, and the immunoregulatory index is 1.5 times higher than in the control group. Neurodegenerative Changes: Proved that non-infectious uveitis promotes rapid neurodegenerative changes in the retina, leading to neuronal and glial cell death and disruption of structural layering. Genetics (ACE gene): Patients with the DD genotype have a higher risk of clinically significant retinal changes during COVID-19 (p<0.001). Retinal Changes in COVID-19: Identified a correlation between the frequency and structure of retinal changes and the severity of COVID-19. In severe cases, cotton wool spots, vascular narrowing, hemorrhages, and thromboses are diagnosed significantly more often. Product Description popup.authors Bohdanova Oleksandra V. Velychko Liudmyla M. Horianova Ilina S. Hutsaliuk Kateryna M. Dorokhova Oleksandra E. Kolesnichenko Viktoriia V. Konovalova Nataliia V. Ponomarchuk Valerii S. Khramenko Nataliia I. popup.nrat_date 2025-03-10 Close