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Information × Registration Number 0225U002596, (0122U001431) , R & D reports Title Mechanisms of the modifying influence of covid-19 on radiation-induced effects in persons suffered from the chornobyl catastrophe popup.stage_title Розробити систему заходів із діагностики та лікування постраждалих внаслідок аварії на ЧАЕС, які зазнали впливу COVID-19. Head Bazyka Dymytrii A., Доктор медичних наук Registration Date 20-03-2025 Organization State Institution "National Research Center for Radiation Medicine, Hematology and Onkology of the National Academy of Medical Sciences of Ukraine" popup.description1 To determine the mechanisms of the modifying influence of COVID-19 on radiation-induced effects in critical systems of organism of persons suffered from the Chornobyl catastrophe for optimization of the diagnosis and treatment of coronavirus disease long-term consequences. popup.description2 The object of the study is the clean-up workers who had COVID-19. The objective of the work is to determine the mechanisms of the modifying effect of COVID-19 on radiation-induced effects in the critical systems of the body of those affected by the Chornobyl accident to optimize the diagnosis and treatment of the long-term consequences of coronavirus disease. Results. The clean-up workers showed pronounced disorders of the respiratory, cardiovascular and nervous systems. In the clean-up workers, the consequences of COVID-19 can be considered a violation of the heart rhythm such as ventricular extrasystoles and atrial fibrillation, a change in the structural and functional state of the myocardium with a decrease in the ejection fraction, an increase in the volume of the right chambers of the heart. The clean-up workers have bilateral cerebral organic damage with a violation of information and cognitive processes of the brain in the dominant and subdominant hemispheres. The clean-up workers who died from COVID-19 had a severe chronic disease or several diseases that aggravated the course of the coronavirus disease and each other and contributed to the development of fatal outcomes. The markers of COVID-19-associated immune system disorders are the indicators of granulocytes, B- and T-cells, CD4+ T-cells expressing activation markers CD25 and CD27, and CD56+ NKT, cytokine-producing lymphocytes and the level of pro- and anti-inflammatory cytokines and NF-κβ. Activation of effector T-cells, NK and NKT, changes in cytokine signaling due to COVID-19 lead to disturbances in immune reactivity and the development of a systemic mild inflammatory response, which can cause the progression of chronic pathology. An algorithm of actions has been developed for damage to the respiratory and cardiovascular systems after COVID-19 infection in persons who suffered from the Chornobyl catastrophe. Product Description popup.authors Ilienko Iryna M. Bieliaiev Oleh A. Bilyi Davyd O. Bazyka Kostiantyn D. Holiarnyk Nataliia A. Diahil Iryna S. Zvarych Liliia M. Kreinis Heorhii Yu. Kuts Kostiantyn V. Liaskivska Olena V. Nastina Оlena M. Panchenko Viktoriia V. Perchuk Iryna V. Pleskach Oksana Ya. Syvak Liubov A. Sushko Viktor O. Chumak Аnatolii A. Shvaiko Liudmyla I. Shylenko Mariia V. Shynkarenko Valentyna I. popup.nrat_date 2025-03-20 Close