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Registration Number

0225U003040, (0120U105219) , R & D reports

Title

Morphofunctional peculiarities of organs and tissues under the influence of external and internal factors

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Вивчення морфогенезу органів і тканин експериментальних тварин та людини при дії зовнішніх і внутрішніх чинників в онтогенезі

Head

Kosharnyi Volodymyr V., Доктор медичних наук

Registration Date

08-05-2025

Organization

State institution "Dnipropetrovsk Medical Academy of the Ministry of Health of Ukraine"

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Investigate the morphogenesis of organs and tissues under the influence of external and internal factors

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 The research has allowed to expand and substantiate the key aspects of structural and functional changes in internal organs after experimental abdominal barotrauma and exposure to heavy metal salts. The research provides a solution to a relevant scientific and practical problem, both for theoretical and practical medicine, which is to determine the structural and reactive transformations of internal organs after experimental abdominal barotrauma. Using modern methods of morphological research (electron microscopy, immunohistochemical analysis), new data were obtained on changes in the structural organization of internal organs after exposure to a blast wave, and pathohistological changes in cellular and tissue elements were assessed during the post-traumatic period. The study of the toxicity of heavy metal salts revealed that their different chemical forms have a variable effect on the body. Some metal citrates showed protective properties, reducing the accumulation of toxic substances in internal organs. The obtained data indicate the critical role of vascular disorders and hypoxia in the pathogenesis of post-traumatic injuries of internal organs, as well as the potential of certain metal complexes as protectors against the toxic effects of heavy metals. The results can be used to develop new strategies for the treatment of abdominal injuries and detoxification of the body. Also, the study can be useful for the further development of therapeutic approaches to protect the body from the negative effects of the blast wave and toxic substances

Product Description

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Abdul-Ohly Larysa V.
Belimenko Mykola S.
Hruzd Vladyslava V.
Zharikov Mykola Yu.
Kytova Iryna V.
Kozlov Serhii V.
Kozlovska Hanna O.
Korzachenko Maksym A.
Kramar Svitlana B.
Kushnarova Kateryna A.
Nefodova Olena O.
Ruthaizer Viktoriia H.
Shevchenko Inna V.
Shevchenko Olena S.
Yanushkevych Kostiantyn S.

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2025-05-08