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0225U004596,
(0125U002395)
,
Polymeric hydrogels for save and efficient vaccines
Оптимізація методів синтезу та складів функціональних гідрогелів - ад'ютантів, їх комплексів з антигенами та дослідження їх токсичності і біоактивності.
Zaichenko Oleksandr S., Доктор хімічних наук
13-12-2025
Lviv Polytechnic National University
Development of a strategy and experimental approaches for obtaining new multicenter hydrogel particles with diverse architectures, functionalities, and morphologies, as well as their application as universal and safe adjuvants for vaccines
Functional hydrogel microparticles with controlled architectures were developed as novel synthetic multisite adjuvants designed to potentiate immune responses and facilitate the creation of effective vaccine formulations. These biocompatible, non-toxic adjuvants—constructed from multisite functional hydrogels of diverse morphologies and size ranges—are capable of binding defined quantities of multiple antigens. The biocompatibility of the developed multisite polymer hydrogels was assessed in vitro by evaluating their effects on survival, proliferation, and metabolic activity of pseudonormal cells (connective and epithelial tissue) and normal cells (human donor peripheral blood mononuclear cells). In vivo toxicity assessments revealed no adverse effects, including the absence of mortality, allergic reactions, or clinical signs of toxicity. Hematological indices, serum biochemical markers, and oxidative stress indicators (SOD, catalase, glutathione, malondialdehyde) in major organs remained within control levels. The hydrogel-based adjuvants exhibited negligible systemic toxicity and did not alter organ mass, hepatic or renal function, or lipid metabolism. Immunogenicity studies in mice using a COVID-19 antigen formulated with the synthesized adjuvants demonstrated robust induction of antigen-specific antibodies. Overall, the developed hydrogels represent a promising platform for next-generation vaccine adjuvants targeting viral and bacterial pathogens.
Natali Mitina
Khryst Harhay
Natali Finiuk
Maria Kozak
Iryna Petrukh
Oleh Izhyk
2025-12-13
Updated: 2025-12-14
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