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Information × Registration Number 0225U004707, (0125U000970) , R & D reports Title Adaptation of the methodology for assessing the effect of biologically active substances using in silico methods on the organism of pigs. popup.stage_title Адаптація методики оцінки впливу біологічно-активних речовин за застосування методів in silico на організм свиней. Head Zinoviev Serhii H., Кандидат сільськогосподарських наук Registration Date 17-12-2025 Organization Institute of pig breeding and agrarian production of The National Academy of Agrarian Scienses popup.description1 To adapt the methodology for assessing the impact of biologically active substances on the pig organism using in silico methods used for preclinical studies of biologically active substances for use in pig production. popup.description2 The aim of the work is to adapt the methodology for assessing the effect of biologically active substances on pigs using in silico methods, which are used for preclinical research of biologically active substances for use in pig breeding. The introduction of computer-aided design methods for biologically active feed additives and veterinary drugs will make it possible to speed up the process of their creation, research, and implementation into practice. This makes it possible to predict the effect of the drug being developed on the body of animals, which in turn will reduce the number of laboratory studies, reagent costs, and, accordingly, environmental pollution. There is no single freely accessible web resource that provides a prediction of the entire set of characteristics necessary for assessing the safety of pharmacologically active substances. In addition, a comparison of different predictive web resources shows that their accuracy and predictive power vary significantly. Therefore, SwissADME, ADMETlab, and pkCSM resources, as well as RDKit, MGLTools, and AutoDock Vina programs, which are free and open source, are used for ADME/DMPK assessment for key bioactive components. Product Description popup.authors Андрій Ф. Курман Artem M. Saienko Nykyforuk Oksana Vasylivna Mariia L. Pushkina Mykyta Y. Peka Dmytro S. Dubinin popup.nrat_date 2025-12-17 Close