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Information × Registration Number 0226U000059, (0121U108470) , R & D reports Title Study of the mechanism of formation of antibiotic resistance of microorganisms, theoretical and experimental substantiation of alternative antibiotic therapeutic methods of treatment and prevention of bacterial diseases of animals and birds popup.stage_title Теоретично і експериментально обґрунтувати використання препаратів бактеріофагів для лікування та профілактики бактеріальних інфекцій тварин та птиці з метою зменшення використання атибіотиків Head Sytiuk Mykola , Доктор ветеринарних наук Registration Date 02-01-2026 Organization Institute of Veterinary Medicine of the National Academy of Agrarian Sciences of Ukraine popup.description1 The aim of the project is to monitor the level of resistance of bacteria - pathogens of infectious diseases of animals and poultry to antibiotics, to study the spread of antibiotic resistance among pathogens and its mechanism of action through molecular genetic studies; theoretically and experimentally substantiate alternative antibiotic therapy methods of treatment and prevention of bacterial diseases of animals and poultry. Epizootological, clinical, bacteriological, biological, molecular genetic research methods will be used to implement the project. popup.description2 The sensitivity of E.coli bacteria was monitored in 30 pig farms of various capacities and regions of Ukraine. The sensitivity of the studied E.coli to antibacterial drugs ranged from 7.2% to 87.5%, and in the period from 2013 to 2021 it already ranged from 7.7% to 30.4%. This trend complicates the choice of means of treating bacterial infections in animals and methods of their control, and also increases the threat of the appearance of such bacteria in human food and contributes to their further circulation in nature. A study of the effect of bacteriophage drugs for the treatment of animal bacteriosis, as an alternative or reduction of exclusively antibiotic therapy, was conducted in 5 livestock farms in Vinnytsia, Zhytomyr, Khmelnytskyi and Volyn regions. Groups of cows with mastitis were treated with antibiotics, antibiotics in combination with bacteriophages, and only bacteriophages. When using antibiotics, mastitis was not detected after therapy in 0% to 7.12% of sick cows, when using antibiotics and bacteriophages in combination, from 50.00% to 100.00% of animals, and when treating exclusively with bacteriophages - also from 50.00% to 100.00% of animals. Thus, the effectiveness of treatment with bacteriophages and in combination with antibiotics has been proven. Research continues. A Concept of using alternative antibiotic therapy for the treatment and prevention of bacterial diseases of animals and poultry has been developed, which has been approved by the Scientific and Methodological Council and approved by the Academic Council of the Institute of Veterinary Medicine of the National Academy of Sciences. Product Description popup.authors Olena Y. Aishpur Dmytro Shai Mykola Sytiuk Yuliia Melnychuk Svitlana Borodenko popup.nrat_date 2026-01-02 Close