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Information × Registration Number 0226U000274, (0124U000206) , R & D reports Title 2-(2Н-Azirin-2-іl)-pyrimidin-4(3Н)-оnes. Synthesis and properties. popup.stage_title Синтез 2-(2Н-aзирин-2-іл)-піримідинiв. Head Yavolovskyi Arkadii O., Доктор хімічних наук Registration Date 07-01-2026 Organization Physico-Chemical Institute O. Bogatsky National Academy of Sciences of Ukraine popup.description1 The aim of planned research is development of methods for synthesis 2-(2H-azirin-2-yl)-pyrimidines and study their main properties. Compounds 2H-azirin class belong to biologically active substances of natural origin with high antibacterial, fungicidal, and cytotoxic activity. The main idea of research is to obtain 2 (2H-azirin-2-yl)-pyrimidines by cyclization of 2-(2-hydroxyimino-2-arylethyl)pyrimidin-4(3H)-ones. Available derivatives of 2-(2-oxo-2-arylethylidene)-2,3-dihydro-1H-pyrimidin-4-ones are expected to be used as starting reagents. popup.description2 The objects of research are 2H-azirines, 2-(2-oxo-2-arylethylsulfanyl)-pyrimidin-4(3H)-ones, 2-(2-hydroxyimino-2-phenylethyl)-6-R-pyrimidin-4(3H)-ones. The aim of the work is to develop effective methods for the synthesis of 2-(2-hydroxyimino-2-phenylethyl)-6-R-pyrimidin-4(3H)-ones as starting materials for the preparation of new 2H-azirine derivatives. Research methods and equipment: PMR spectroscopy (Varian WXP-500), mass spectrometry (MX 1321), TLC. A one-step method for the synthesis of 2-(2H-azirin-2-yl)-pyrimidin-4(3H)-ones by the reaction of 2-(2-oxo-2-arylethylidene)-2,3-dihydropyrimidin-4(1H)-ones with TsCl and Et3N as bases has been developed. It has been shown that under the proposed conditions, the formation of a by-product – 6-phenyl-2-(3-phenyl-2H-azirin-2-yl)pyrimidin-4-yl-4-methylbenzosulfonate – is possible. The structure of the newly obtained compounds was established using 1H NMR spectroscopy and mass spectrometry. A potential area of use for the synthesized and studied materials is chemical, pharmaceutical, and biomedical monitoring. Product Description popup.authors Arkadii О. Yavolovskyi Pluzhnyk-Hladyr Serhii M. Stepanov Dmytro Ye. Hryshchuk Lidiia V. Yurii E. Ivanov popup.nrat_date 2026-01-07 Close