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Information × Registration Number 0226U000438, (0124U000707) , R & D reports Title To develop differentiated treatment and rehabilitation measures for military personnel and civilians, victims of hostilities, patients with chronic non-specific lung diseases, taking into account functional changes of the cardiorespiratory system. popup.stage_title Розробити прогностичні критерії працездатності військовослужбовців та цивільних осіб, постраждалих від бойових дій, хворих на хронічні неспецифічні захворювання легень. Head Feshchenko Yurii I., Доктор медичних наук Registration Date 09-01-2026 Organization State organization "National scientific center of phthisiatry, pulmonology and allergology named after F. G. Yanovskyi National academy of medical sciences of Ukraine" popup.description1 To develop the technology, treatment, rehabilitation and restoration of working capacity of military personnel and civilians affected by hostilities, patients with chronic non-specific lung diseases, taking into account the functional state of the cardiorespiratory system. popup.description2 Object: 307 patients: 197 military personnel with verified combat experience, 50 civilians exposed to combat-related factors and 60 individuals in a control group with no exposure to armed conflict. The aim: to develop a technology for the treatment, rehabilitation, and restoration of work capacity in military personnel and civilians affected by hostilities who have chronic nonspecific lung diseases, taking into account the functional state of the cardiorespiratory system. Methods: clinical-functional, instrumental, statistical. It was established that a highly specific combat-associated phenotype of chronic respiratory diseases is formed, which manifests as an accelerated rate of structural and functional remodeling of the respiratory system. Among military personnel with combat experience, a significantly higher annual decline in FEV₁(>55 mL/year) and a progressive decrease in DLCO(0.75-1.0%/year) were recorded compared with the control group, which indicates persistent damage to the alveolar-capillary barrier as a result of combined inhalational and stress-related effects. The frequency of symptomatic decompensation amounted to 65.0% versus 48.0% in the control group, accompanied by neurovegetative dysregulation and pronounced psychoemotional disorders. Correlation-regression analysis demonstrated close associations between clinical and psychoemotional markers (CAT, mMRC, SGRQ, CD-RISC, MIES; r = 0.62-0.71), which confirms the multilevel mechanism of maladaptation, within which somatic, ventilatory-diffusion, and neurobehavioral determinants form a single pathogenetic contour. An algorithm for predicting the risk of work-capacity loss in military personnel with CNLD associated with combat experience was developed, which makes it possible to detect signs of progressive decline in functional reserves 1.5 years before clinically manifest changes appear, achieving high predictive accuracy: sensitivity – 82.5%, specificity – 78.3%. Sphere of application – pulmonology. Product Description popup.authors Svitlana A. Bychkova Lesia M. Kuryk Nataliia V. Parkhomenko Nataliia A. Prymushko Olena I. Krylach Oleksandr A. Kanarskyi Yurii I. Feshchenko Inna P. Turchyna popup.nrat_date 2026-01-09 Close