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Information × Registration Number 0226U000442, (0125U000462) , R & D reports Title To improve the approaches of differential diagnosis and treatment of pulmonary tuberculosis combined with concomitant diseases and conditions in the conditions of martial law. popup.stage_title Обґрунтувати значимість впливу на ефективність лікування та якість життя пацієнтів поєднання туберкульозу легень та супутніх захворювань або станів в умовах воєнного стану. Head Lytvynenko Nataliia A., Доктор медичних наук Registration Date 09-01-2026 Organization State organization "National scientific center of phthisiatry, pulmonology and allergology named after F. G. Yanovskyi National academy of medical sciences of Ukraine" popup.description1 To determine the approaches of differential diagnosis and treatment of pulmonary tuberculosis combined with concomitant diseases in the conditions of martial law, which will allow to increase the effectiveness of treatment and the quality of life of patients by reducing the time of diagnosis of concomitant diseases and conditions or repeated episodes of tuberculosis disease, improving the complex treatment of combined pulmonary tuberculosis with concomitant diseases and conditions and the use of methods of normalization of the state of mental health popup.description2 The object is 2017 patients with tuberculosis (TB). The goal is to determine approaches to differential diagnosis and treatment of pulmonary TB combined with concomitant diseases in martial law conditions, which will allow to increase the effectiveness of treatment and quality of life of patients by reducing the time of diagnosis of concomitant diseases and conditions or repeated episodes of TB disease, improving the complex treatment of pulmonary TB combined with concomitant diseases and conditions, and applying methods for normalizing the state of mental health. Methods - clinical, radiological, laboratory, statistical. Among patients with various forms of TB, the frequency of: main concomitant diseases of the lungs (27.1 %); concomitant diseases of other organs and systems, including impaired mental health (40.4 %); conditions such as complications of TB and adverse events (37.5 %). The following factors negatively affected the timeliness of active TB: the presence of drug-resistant TB (DR-TB), concomitant lung diseases with organic irreversible changes (bronchiectasis, pneumofibrosis, emphysema, aspergillosis). Risk groups for DR-TB treatment failure were: the unemployed, the disabled, pensioners, people without a permanent place of residence, people with addictions, with AE, and with the highest degree of connection military personnel. It was found that TB treatment was more often ineffective in: medical risk groups that included various types of concomitant diseases, including HIV and diabetes mellitus (16.0 %); close contacts with TB (4.9 %). It was found that before the start of treatment, military personnel had a significantly worse mental health status in terms of anxiety (in 61.5% versus 55.7 %) and depression (in 93.6 % versus 67.6 %). It was determined that AE, as one of the significant concomitant conditions, were registered in 14.9-55.4 % of patients on TB drugs who received short-term treatment regimens. Sphere of application – tuberculosis. Product Description popup.authors Nataliia A. Lytvynenko Veselovsky Leonid Viktorovych Serhii V. Zaykov Juliya O. Senko Maryna V. Pogrebna Valentyna V. Davydenko Chobotar Oksana P. Shcherbakova Lesia V. Oleksandr A. Zhurylo Anna I. Barbova Liubomyr M. Protsyk Anastasiia S. Lafeta Nataliia A. Hritsova Korotchenko Svitlana P. Kateryna K. Buchak popup.nrat_date 2026-01-09 Close