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Information × Registration Number 0226U000444, (0125U000465) , R & D reports Title To investigate the features of the complicated course of the bronchial asthma severe exacerbations in military personnel and civilians injured as a result of military operations, and to work out the technology for their treatment popup.stage_title Установити клініко-функціональні характеристики ускладненого перебігу тяжких загострень бронхіальної астми у військовослужбовців та цивільних осіб, постраждалих внаслідок воєнних дій Head Polianska Maryna O., к.мед.н.Feshchenko Yurii I., Доктор медичних наук Registration Date 09-01-2026 Organization State organization "National scientific center of phthisiatry, pulmonology and allergology named after F. G. Yanovskyi National academy of medical sciences of Ukraine" popup.description1 To increase the effectiveness of treatment of patients with the complicated course of the bronchial asthma severe exacerbations in military personnel and civilians injured as a result of military operations popup.description2 Object – 100 patients with severe asthma (among them 40 military personnel and 60 civilians); 45 white laboratory rats. Aim – to increase the effectiveness of treatment of patients with the complicated course of the bronchial asthma severe exacerbations in military personnel and civilians injured as a result of military operations. Methods – questionnaire, clinical, functional, radiological, experimental, biochemistry, statistical. Clinical and functional characteristics of severe BA exacerbations in military personnel and civilians injured as a result of military operations are uncontrolled asthma (according to ACT (10,7 ± 0,6) and (12,5 ± 0,5) points and ACQ (2,9 ± 0,1) and (2,7 ± 0,1) points, respectively), high level of dyspnoea (according to mMRC (2,6 ± 0,1) and (2,3 ± 0,1) points, respectively), decreased vital and forced vital capacity; decreased FEV1 to (60,2 ± 2,4) % in military personnel and (63,2 ± 2,7) % in civilians, severe bronchial obstruction, at the level of small bronchi also, decreased tolerance to physical activity. According to the X-ray examination patients with severe BA exacerbations have concomitant respiratory diseases: bronchiolitis, pneumonia, fibrosis, sarcoidosis, pneumoconiosis. It was established that most patients had comorbidity, mainly allergic and cardiovascular diseases. Among other pulmonary diseases in addition to BA, concomitant COPD and pneumonia were observed. In experimental pulmonary emphysema, the activity of glutathione metabolism enzymes is decreased: glutathione-reductase, glutathione-S-transferase and glutathione-peroxidase in the blood. An algorithm for diagnosing of the complicated course of the bronchial asthma severe exacerbations in military personnel and civilians injured as a result of military operations has been developed, the use of which allows to increase the accuracy of bronchiolitis diagnosis by 23,5 %. Sphere of application – therapy, pulmonology, allergology. Product Description popup.authors Galyna L. Gumeniuk Svitlana H. Opimakh Svitlana M. Moskalenko Lesia M. Kuryk Korzhov Vitaliy Ivanovych Nataliia V. Parkhomenko Victoriia I. Ihnatieva Inna V. Zvol Chumak Iryna V. Maryna O. Polianska Halai Liudmyla A. Prymusko Nataliia A. Vlasova Nataliia A. Yurii I. Feshchenko popup.nrat_date 2026-01-09 Close