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Information × Registration Number 0226U000859, (0124U003825) , R & D reports Title Elaboration of technology of anti-inflammatory perioperative therapy in radiofrequency ablation of colorectal cancer liver metastases popup.stage_title Розробка схем протизапальної періопераційної терапії при радіочастотній абляції метастазів в печінку Head Krasnoselskyi Mykola V., Доктор медичних наукSorochan Pavlo P., Кандидат медичних наук Registration Date 16-01-2026 Organization State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine" popup.description1 Increasing the antitumor efficacy of radiofrequency ablation of colorectal cancer liver metastases by developing a technology of anti-inflammatory drug perioperative therapy taking into account predictive markers of inflammatory response popup.description2 Object of the study: radiofrequency ablation of colorectal cancer liver metastases. Purpose: increasing the antitumor efficacy of radiofrequency ablation of colorectal cancer liver metastases by developing a technology of anti-inflammatory drug perioperative therapy taking into account predictive markers of inflammatory response. Methods and equipment: immunological, hematological, biochemical, clinical, morphological, statistical methods; light microscopes, flow cytofluorometer, biochemical, hematological and immune enzyme analyzers. Theoretical and practical results: A perioperative treatment scheme for patients undergoing radiofrequency ablation, which includes propranolol and metformin, has been proposed. It has been established that perioperative treatment according to this scheme reduces the neutrophil-lymphocyte ratio and inflammatory mediator levels, affects the balance of CD4+ and CD8+ T-lymphocytes, and improves insulin sensitivity, coagulogram parameters and patients’ quality of life in the postoperative period. It has been proven that the treatment effect also depends on the initial hemato-immune state of the cancer patient's body. Novelty: A new perioperative treatment scheme was developed, which included propranolol and metformin. A complex of effects of this drug combination of drugs, capable of improving the further course of the oncological disease, was determined. Implementation efficiency: improved effectiveness of treatment. Field of application: oncology, medical immunology. Product Description popup.authors Neonila O. Artamonova Maryna O. Ivanenko Gennadii V. Grechikhin Olena V. Kuzmenko Dmitry V. Olkhovsky Nataliia E. Prokhach Fedir Hladkykh Iryna A. Hromakova Inna S. Hromakova Iryna V. Kosheleva Viktoriia O. Tepla Maryna Y. Tretiak Svitlana I. Revenkova Halyna V. Kulinich Olha Y. Dubenko Svitlana V. Chekanova Eduard V. Podrez popup.nrat_date 2026-01-16 Close