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Registration Number

0226U000859, (0124U003825) , R & D reports

Title

Elaboration of technology of anti-inflammatory perioperative therapy in radiofrequency ablation of colorectal cancer liver metastases

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Розробка схем протизапальної періопераційної терапії при радіочастотній абляції метастазів в печінку

Head

Krasnoselskyi Mykola V., Доктор медичних наук
Sorochan Pavlo P., Кандидат медичних наук

Registration Date

16-01-2026

Organization

State Organization "Grigoriev Institute for Medical Radiologiy and Oncology of the National Academy of Medical Sciences of Ukraine"

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Increasing the antitumor efficacy of radiofrequency ablation of colorectal cancer liver metastases by developing a technology of anti-inflammatory drug perioperative therapy taking into account predictive markers of inflammatory response

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Object of the study: radiofrequency ablation of colorectal cancer liver metastases. Purpose: increasing the antitumor efficacy of radiofrequency ablation of colorectal cancer liver metastases by developing a technology of anti-inflammatory drug perioperative therapy taking into account predictive markers of inflammatory response. Methods and equipment: immunological, hematological, biochemical, clinical, morphological, statistical methods; light microscopes, flow cytofluorometer, biochemical, hematological and immune enzyme analyzers. Theoretical and practical results: A perioperative treatment scheme for patients undergoing radiofrequency ablation, which includes propranolol and metformin, has been proposed. It has been established that perioperative treatment according to this scheme reduces the neutrophil-lymphocyte ratio and inflammatory mediator levels, affects the balance of CD4+ and CD8+ T-lymphocytes, and improves insulin sensitivity, coagulogram parameters and patients’ quality of life in the postoperative period. It has been proven that the treatment effect also depends on the initial hemato-immune state of the cancer patient's body. Novelty: A new perioperative treatment scheme was developed, which included propranolol and metformin. A complex of effects of this drug combination of drugs, capable of improving the further course of the oncological disease, was determined. Implementation efficiency: improved effectiveness of treatment. Field of application: oncology, medical immunology.

Product Description

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Neonila O. Artamonova
Maryna O. Ivanenko
Gennadii V. Grechikhin
Olena V. Kuzmenko
Dmitry V. Olkhovsky
Nataliia E. Prokhach
Fedir Hladkykh
Iryna A. Hromakova
Inna S. Hromakova
Iryna V. Kosheleva
Viktoriia O. Tepla
Maryna Y. Tretiak
Svitlana I. Revenkova
Halyna V. Kulinich
Olha Y. Dubenko
Svitlana V. Chekanova
Eduard V. Podrez

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2026-01-16